Rodopsin kinaza
(преусмерено са Rodopsinska kinaza)
Rodopsin kinaza (EC 2.7.11.14, kupasti opsin kinaza, G-protein-spregnuti receptor kinaza 1, GPCR kinaza 1, GRK1, GRK7, opsinska kinaza, opsinska kinaza (fosforilacija), rodopsinska kinaza (fosforilacija), RK, STK14) je enzim sa sistematskim imenom ATP:rodopsin fosfotransferaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Rodopsin kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.14 | ||||||||
| CAS broj | 54004-64-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + rodopsin ADP + fosforhodopsin
G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).
Reference
уреди- ^ Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. (1986). „Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase”. Nature. 321: 869—872. PMID 3014340.
- ^ Shichi, H. & Somers, R.L. (1978). „Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase”. J. Biol. Chem. 253: 7040—7046. PMID 690139.
- ^ Palczewski, K., McDowell, J.H. and Hargrave, P.A. (1988). „Purification and characterization of rhodopsin kinase”. J. Biol. Chem. 263: 14067—14073. PMID 2844754.
- ^ Weller, M., Virmaux, N. and Mandel, P. (1975). „Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin”. Proc. Natl. Acad. Sci. USA. 72: 381—385. PMID 164024.
- ^ Cha, K., Bruel, C., Inglese, J. and Khorana, H.G. (1997). „Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications”. Proc. Natl. Acad. Sci. USA. 94: 10577—10582. PMID 9380677.
- ^ Khani, S.C., Abitbol, M., Yamamoto, S., Maravic-Magovcevic, I. and Dryja, T.P. (1996). „Characterization and chromosomal localization of the gene for human rhodopsin kinase”. Genomics. 35: 571—576. PMID 8812493.
- ^ Chen, C.K., Zhang, K., Church-Kopish, J., Huang, W., Zhang, H., Chen, Y.J., Frederick, J.M. and Baehr, W. (2001). „Characterization of human GRK7 as a potential cone opsin kinase”. Mol. Vis. 7: 305—313. PMID 11754336.
- ^ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626—633. PMID 14654303.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Rhodopsin+kinase на US National Library of Medicine Medical Subject Headings (MeSH)