Izoksazol

Izoksazol
Nazivi
	IUPAC naziv izoksazol
Identifikacija
CAS broj	288-14-2;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:35595 ;
ChemSpider	8897 ;
ECHA InfoCard	100.005.472
PubChem C ID	9254;
	SMILES n1occc1; ; ; ; ; ;
Svojstva
Hemijska formula	C3H3NO
Molarna masa	69,06202
Gustina	1,075 g/ml
Tačka ključanja	95 °C
Kiselost (pKa)	-3.0 (za konjugovanu kiselinu)
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Izoksazol je azol sa atomom kiseonika pored azota. Izoksazol je isto tako naziv za klasu jedinjenja koja sadrže ovaj prsten.^[4]^[5]

Izoksazolni prsteni su nađeni u prirodnim proizvodima, npr. u ibotenskoj kiselini. Izoksazoli takođe formiraju bazu za brojne lekove, među kojima je COX-2 inhibitor valdekoksib (Bekstra). Derivat izoksazola, furoksan, je donor azot monoksida.

Reference

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Zoltewicz, J. A. & Deady, L. W. Quaternization of heteroaromatic compounds. Quantitative aspects. Adv. Heterocycl. Chem. 22, 71-121 (1978).
^ Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.
^ Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.

Vidi još

Spoljašnje veze

Sinteza izoksazola

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Zoltewicz, J. A. & Deady, L. W. Quaternization of heteroaromatic compounds. Quantitative aspects. Adv. Heterocycl. Chem. 22, 71-121 (1978).

[Katritzky2nd-4] Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.

[Clayden1st-5] Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.

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