CCL21
CCL21, hemokin (C-C motiv) ligand 21, je mali citokin iz CC hemokin familije. Ovaj hemokin je takođe poznat kao 6Ckine (zato što ima šest konzerviranih cisteinskih ostataka umesto četiri cisteina kao što je tipično za hemokine), exodus-2, i sekondarni hemokin limfoidnog-tkiva (SLC).[1][2][3] Gen za CCL21 je lociran na ljudskom hromozom 9. CCL21 dejstvuje putem vezivanja za hemokinski receptor na ćelijskoj površini pod imenom CCR7.[4][5]
| Hemokin (C-C motiv) ligand 21 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | CCL21; 6Ckine; CKb9; ECL; MGC34555; SCYA21; SLC; TCA4 | ||||||||||
| Vanjski ID | OMIM: 602737 HomoloGene: 88457 GeneCards: CCL21 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6366 | n/a | |||||||||
| Ensembl | ENSG00000137077 | n/a | |||||||||
| UniProt | O00585 | n/a | |||||||||
| RefSeq (mRNA) | NM_002989 | n/a | |||||||||
| RefSeq (protein) | NP_002980 | n/a | |||||||||
| Lokacija (UCSC) |
Chr 9: 34.7 - 34.7 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
Reference
уреди- ^ Hedrick JA, Zlotnik A (1997). „Identification and characterization of a novel beta chemokine containing six conserved cysteines”. J. Immunol. 159 (4): 1589—93. PMID 9257816.
- ^ Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (1997). „Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension”. J. Immunol. 159 (6): 2554—8. PMID 9300671.
- ^ Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). „Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13”. J. Biol. Chem. 272 (31): 19518—24. PMID 9235955. doi:10.1074/jbc.272.31.19518.
- ^ Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O (1998). „Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7”. J. Biol. Chem. 273 (12): 7118—22. PMID 9507024. doi:10.1074/jbc.273.12.7118.
- ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
Literatura
уредиDodatna literatura
уреди- Nagira M; Imai T; Hieshima K; et al. (1997). „Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13.”. J. Biol. Chem. 272 (31): 19518—24. PMID 9235955. doi:10.1074/jbc.272.31.19518.
- Hedrick JA, Zlotnik A (1997). „Identification and characterization of a novel beta chemokine containing six conserved cysteines.”. J. Immunol. 159 (4): 1589—93. PMID 9257816.
- Hromas R; Kim CH; Klemsz M; et al. (1997). „Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension.”. J. Immunol. 159 (6): 2554—8. PMID 9300671.
- Gunn MD; Tangemann K; Tam C; et al. (1998). „A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.”. Proc. Natl. Acad. Sci. U.S.A. 95 (1): 258—63. PMC 18193
. PMID 9419363. doi:10.1073/pnas.95.1.258. - Yoshida R; Nagira M; Kitaura M; et al. (1998). „Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7.”. J. Biol. Chem. 273 (12): 7118—22. PMID 9507024. doi:10.1074/jbc.273.12.7118.
- Campbell JJ; Bowman EP; Murphy K; et al. (1998). „6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7.”. J. Cell Biol. 141 (4): 1053—9. PMC 2132769 . PMID 9585422. doi:10.1083/jcb.141.4.1053.
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- Nagakubo D; Murai T; Tanaka T; et al. (2003). „A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines.”. J. Immunol. 171 (2): 553—61. PMID 12847218.
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