Butirat-KoA ligaza
Butirat-KoA ligaza (EC 6.2.1.2, butiril-KoA sintetaza, masno kiselinska tiokinaza (lanca srednje dužine), acil-altivirajući enzim, masno kiselinska elongaza, masno kiselinski aktivirajući enzim, masna acil koenzim A sintetaza, sintetaza acil-KoA srednje dužine lanca, butiril-koenzim A sintetaza, L-(+)-3-hidroksibutiril KoA ligaza, sintetaza acil-KoA kratkog lanca) je enzim sa sistematskim imenom butanoat:KoA ligaza (formira AMP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Butirat-KoA ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.2.1.2 | ||||||||
| CAS broj | 9080-51-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + karboksilat + KoA AMP + difosfat + acil-KoA
Ovaj enzim deluje na kiseline sa C4 do C11 dugim lancom.
Reference
уреди- ^ Mahler, H.R., Wakil, S.J. and Bock, R.M. (1953). „Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids”. J. Biol. Chem. 204: 453—468. PMID 13084616.
- ^ Massaro, E.J. & Lennarz, W.J. (1965). „The partial purification and characterization of a bacterial fatty acyl coenzyme A synthetase”. Biochemistry. 4: 85—90. PMID 14285249.
- ^ Websterlt, J.R., Gerowin, L.D. and Rakita, L. (1965). „Purification and characteristics of a butyryl coenzyme A synthetase from bovine heart mitochondria”. J. Biol. Chem. 240: 29—33. PMID 14253428.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Butyrate---CoA+ligase на US National Library of Medicine Medical Subject Headings (MeSH)
