B-galaktozid a-2,6-sijaliltransferaza
B-galaktozid a-2,6-sijaliltransferaza (EC 2.4.99.1, CMP-N-acetilneuraminat:beta-D-galaktozil-1,4-N-acetil-beta-D-glukozamin alfa-2,6-N-acetilneuraminiltransferaza) je enzim sa sistematskim imenom CMP-N-acetilneuraminat:beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozamin alfa-(2->6)-N-acetilneuraminiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| B-galaktozid a-2,6-sijaliltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.1 | ||||||||
| CAS broj | 9075-81-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- CMP-N-acetilneuraminat + beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozamin CMP + alfa-N-acetilneuraminil-(2->6)-beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozamin
Terminalni beta-D-galaktozilni ostatak oligosaharida glikoproteina, kao i laktoza, mogu da deluju kao akceptori.
Reference
уреди- ^ Bartholomew, B.A., Jourdian, G.W. and Roseman, S. (1973). „The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum”. J. Biol. Chem. 248: 5751—5762. PMID 4723915.
- ^ Hickman, J., Ashwell, G., Morell, A.G., van der Hamer, C.J.A. and Scheinberg, I.H. (1970). „Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin”. J. Biol. Chem. 245: 759—766. PMID 4313609.
- ^ Paulson, J.C., Beranek, W.E. and Hill, R.L. (1977). „Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose”. J. Biol. Chem. 252: 2356—2362. PMID 849932.
- ^ Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G. (1983). „Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type”. Methods Enzymol. 98: 98—134. PMID 6366476.
- ^ Spiro, M.H. & Spiro, R.G. (1968). „Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase”. J. Biol. Chem. 243: 6520—6528. PMID 5726897.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Beta-galactoside+alpha-2,6-sialyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
