Antireumatski lek

Antireumatski lekovi (DMARDs) su kategorija lekova koji se koriste za tretman reumatoidnog artritisa. Njima se usporava progresija bolesti.^[1]^[2].^[3]

Članovi

Lek	Mehanizam
abatacept	T-ćelijski kostimulatorni inhibitor signala
adalimumab	TNF inhibitor
azatioprin	Inhibitor purinske sinteze
hlorohin i hidroksihlorohin (antimalarijali)	Supresija IL-1 & TNF-alfa, indukuje apoptozu inflamatornih ćelija i umanjuje hemotaksu
ciclosporin (Ciklosporin A)	kalcineurinski inhibitor
D-penicilamin	Redukuje broj T-limfocita etc.
etanercept	TNF receptor
golimumab	TNF inhibitor
Soli zlata (natrijum aurotiomalat, auranofin)	unknown
infliksimab	TNF inhibitor
leflunomid	Inhibitor sinteze pirimidina
metotreksat (MTX)	Inhibitor sinteze purina
minociklin	5-LO inhibitor
rituksimab	himerno monoklonalno antitelo protiv CD20 na površini B-ćelija
sulfasalazin (SSZ)	Supresuje IL-1 & TNF-alfa, indukuje apoptozu inflamatornih ćelije i povišava nivo hemotaktičkih faktora

Mada ovi agensi deluju putem različitih mehanizama, mnogi od njih imaju sličan impakt na tok oboljenja.^[4] Neki od ovih lekova se mogu koristiti u kombinaciji.^[5]

Reference

^ „disease-modifying antirheumatic drug at Dorland's Medical Dictionary”.
^ „Disease modifying antirheumatic drugs (DMARDs)”. Архивирано из оригинала 26. 04. 2009. г.
^ „Antirheumatic at Dorland's Medical Dictionary”.
^ Nandi P, Kingsley GH, Scott DL (2008). „Disease-modifying antirheumatic drugs other than methotrexate in rheumatoid arthritis and seronegative arthritis”. Current opinion in rheumatology. 20 (3): 251—6. PMID 18388514. doi:10.1097/BOR.0b013e3282fb7caa.
^ Capell, H. A.; Madhok, R.; Porter, D. R.; et al. (2007). „Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double‐blind placebo‐controlled MASCOT study”. Annals of the rheumatic diseases. 66 (2): 235—41. PMC 1798490  . PMID 16926184. doi:10.1136/ard.2006.057133.

[1] „disease-modifying antirheumatic drug at Dorland's Medical Dictionary”.

[urlDisease_modifying_antirheumatic_drugs_(DMARDs)-2] „Disease modifying antirheumatic drugs (DMARDs)”. Архивирано из оригинала 26. 04. 2009. г.

[3] „Antirheumatic at Dorland's Medical Dictionary”.

[pmid18388514-4] Nandi P, Kingsley GH, Scott DL (2008). „Disease-modifying antirheumatic drugs other than methotrexate in rheumatoid arthritis and seronegative arthritis”. Current opinion in rheumatology. 20 (3): 251—6. PMID 18388514. doi:10.1097/BOR.0b013e3282fb7caa.

[pmid16926184-5] Capell, H. A.; Madhok, R.; Porter, D. R.; et al. (2007). „Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double‐blind placebo‐controlled MASCOT study”. Annals of the rheumatic diseases. 66 (2): 235—41. PMC 1798490  . PMID 16926184. doi:10.1136/ard.2006.057133.

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