Arahidonat 5-lipoksigenaza

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PubMed	članci
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Arachidonat 5-lipoksigenaza
Arachidonat 5-lipoksigenaza
Identifikatori
EC broj	1.13.11.34
CAS broj	80619-02-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Arahidonat 5-lipoksigenaza (EC 1.13.11.34, leukotrien-A4 sintaza, Delta5-lipoksigenaza, 5Delta-lipoksigenaza, arahidonska 5-lipoksigenaza, arahidonska kiselina 5-lipoksigenaza, C-5-lipoksigenaza, LTA sintaza, leukotrienska A4 sintaza) je enzim sa sistematskim imenom arachidonat:kiseonik 5-oksidoreduktaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

arahidonat + O₂

\rightleftharpoons

leukotrien A4 + H₂O (sveukupna reakcija)

(1a) arahidonat + O₂

\rightleftharpoons

(6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat

(1b) (6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat

\rightleftharpoons

leukotrien A4 +H₂O

Reference

^ Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B. (1988). „Molecular cloning and amino acid sequence of human 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA. 85: 26—30. PMID 2829172.
^ Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A₄ hydrolase in the human lung. Inactivation of the enzyme with leukotriene A₄ isomers”. J. Biol. Chem. 262: 10200—10205. PMID 3038871.
^ Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rädmark, O. and Samuelsson, B. (1986). „Characterization of leukotriene A₄ synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA. 83: 4175—4179. PMID 3012557.
^ Shimizu, T., Rädmark, O. and Samuelssohn, B. (1984). „Enzyme with dual lipoxygenase activities catalyzes leukotriene A₄ synthesis from arachidonic acid”. Proc. Natl. Acad. Sci. USA. 81: 689—693. PMID 6322165.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Arachidonate+5-lipoxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B. (1988). „Molecular cloning and amino acid sequence of human 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA. 85: 26—30. PMID 2829172.

[2] Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A₄ hydrolase in the human lung. Inactivation of the enzyme with leukotriene A₄ isomers”. J. Biol. Chem. 262: 10200—10205. PMID 3038871.

[3] Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rädmark, O. and Samuelsson, B. (1986). „Characterization of leukotriene A₄ synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA. 83: 4175—4179. PMID 3012557.

[4] Shimizu, T., Rädmark, O. and Samuelssohn, B. (1984). „Enzyme with dual lipoxygenase activities catalyzes leukotriene A₄ synthesis from arachidonic acid”. Proc. Natl. Acad. Sci. USA. 81: 689—693. PMID 6322165.

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