PRIM2
Велика подјединица ДНК примаже је ензим који је код људи кодиран PRIM2 геном.[1][2]
| Primaza, DNK, polipeptid 2 (58kDa) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Доступне структуре | |||||||||||
| 3L9Q, 3Q36, 4BPU, 4BPW, 4BPX | |||||||||||
| Идентификатори | |||||||||||
| Симболи | PRIM2; PRIM2A; p58 | ||||||||||
| Вањски ИД | OMIM: 176636 MGI: 97758 HomoloGene: 731 GeneCards: PRIM2 Gene | ||||||||||
| ЕЦ број | 2.7.7.- | ||||||||||
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| Преглед РНК изражавања | |||||||||||
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| подаци | |||||||||||
| Ортолози | |||||||||||
| Врста | Човек | Миш | |||||||||
| Ентрез | 5558 | 19076 | |||||||||
| Eнсембл | ENSG00000146143 | ENSMUSG00000026134 | |||||||||
| UниПрот | P49643 | P33610 | |||||||||
| Реф. Секв. (иРНК) | NM_000947 | NM_008922.1 | |||||||||
| Реф. Секв. (протеин) | NP_000938 | NP_032948.1 | |||||||||
| Локација (УЦСЦ) |
Chr 6: 57.18 - 57.51 Mb |
Chr 1: 33.45 - 33.67 Mb | |||||||||
| ПубМед претрага | [1] | [2] | |||||||||
Референце
уреди- ^ Shiratori A; Okumura K; Nogami M; Taguchi H; Onozaki T; Inoue T; Ando T; Shibata T; Izumi M; Miyazawa H; et al. (1996). „Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12”. Genomics. 28 (2): 350—3. PMID 8530050. doi:10.1006/geno.1995.1155.
- ^ „Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa”.
Литература
уреди- Stadlbauer F; Brueckner A; Rehfuess C; et al. (1994). „DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.”. Eur. J. Biochem. 222 (3): 781—93. PMID 8026492. doi:10.1111/j.1432-1033.1994.tb18925.x.
- Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Coll JM; Hickey RJ; Cronkey EA; et al. (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11–12): 629—39. PMID 9563011.
- Schneider A; Smith RW; Kautz AR; et al. (1998). „Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit”. J. Biol. Chem. 273 (34): 21608—15. PMID 9705292. doi:10.1074/jbc.273.34.21608.
- Arezi B, Kirk BW, Copeland WC, Kuchta RD (1999). „Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit”. Biochemistry. 38 (39): 12899—907. PMID 10504261. doi:10.1021/bi9908991.
- Smith RW, Nasheuer HP (2002). „Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180”. FEBS Lett. 527 (1–3): 143—6. PMID 12220650. doi:10.1016/S0014-5793(02)03197-6.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Mungall AJ; Palmer SA; Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Rush J; Moritz A; Lee KA; et al. (2005). „Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94—101. PMID 15592455. doi:10.1038/nbt1046.
