UGT1A7

UDP-glukuronoziltransferaza 1 familija, polipeptid A7 je enzim koji je kod ljudi kodiran genom UGT1A7.

UGT1A7
Identifikatori
Alijasi	UGT1A7
Spoljašnji ID	OMIM: 606432 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A7
Genska lokacija (miš) Hr. Chromosome 1 (mouse) Band 1|1 D Start 87,998,522 bp Kraj 88,146,719 bp
Genska ontologija Molecular function • transferase activity • GO:0048551 enzyme inhibitor activity • retinoic acid binding • hexosyltransferase activity • protein homodimerization activity • glycosyltransferase activity • glucuronosyltransferase activity • protein heterodimerization activity • enzyme binding • protein kinase C binding • UDP-glycosyltransferase activity Cellular component • sastavni deo membrane • endoplasmic reticulum membrane • membrana • intracellular membrane-bounded organelle • endoplazmatični retikulum Biological process • sistem za izlučivanje • coumarin metabolic process • retinoic acid metabolic process • negative regulation of cellular glucuronidation • Metabolizam masnih kiselina • Glukuronidacija • flavonoid glucuronidation • xenobiotic glucuronidation • flavone metabolic process • metabolizam • negative regulation of glucuronosyltransferase activity • negative regulation of fatty acid metabolic process • GO:0048553 negativno regulisanje katalitičke aktivnosti Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	54577	394434
Ensembl	ENSG00000244122	ENSMUSG00000090175
UniProt	Q9HAW7	Q62452
RefSeq (mRNA)	NM_019077	NM_201644
RefSeq (protein)	NP_061950	NP_964006
Location (UCSC)	n/a	Chr 1: 88 – 88.15 Mb
PubMed search
Wikidata
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Literatura

• Tukey RH, Strassburg CP (2000). „Human UDP-glucuronosyltransferases: metabolism, expression, and disease”. Annual Review of Pharmacology and Toxicology. 40: 581—616. PMID 10836148. doi:10.1146/annurev.pharmtox.40.1.581. 
• Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE (oktobar 2000). „Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene”. Pharmacogenetics. 10 (7): 629—44. PMID 11037804. doi:10.1097/00008571-200010000-00006. CS1 održavanje: Format datuma (veza)
• Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC (jun 2001). „Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus”. Pharmacogenetics. 11 (4): 357—68. PMID 11434514. doi:10.1097/00008571-200106000-00011. CS1 održavanje: Format datuma (veza)
• King CD, Rios GR, Green MD, Tephly TR (septembar 2000). „UDP-glucuronosyltransferases”. Current Drug Metabolism. 1 (2): 143—61. PMID 11465080. doi:10.2174/1389200003339171. CS1 održavanje: Format datuma (veza)
• Zheng Z, Park JY, Guillemette C, Schantz SP, Lazarus P (septembar 2001). „Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk”. Journal of the National Cancer Institute. 93 (18): 1411—8. PMID 11562393. doi:10.1093/jnci/93.18.1411 . CS1 održavanje: Format datuma (veza)
• Vogel A, Kneip S, Barut A, Ehmer U, Tukey RH, Manns MP, Strassburg CP (novembar 2001). „Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene”. Gastroenterology. 121 (5): 1136—44. PMID 11677206. doi:10.1053/gast.2001.28655 . CS1 održavanje: Format datuma (veza)
• Strassburg CP, Vogel A, Kneip S, Tukey RH, Manns MP (jun 2002). „Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer”. Gut. 50 (6): 851—6. PMC 1773251 . PMID 12010889. doi:10.1136/gut.50.6.851. CS1 održavanje: Format datuma (veza)
• Vogel A, Ockenga J, Ehmer U, Barut A, Kramer FJ, Tukey RH, Manns MP, Strassburg CP (jul 2002). „Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer”. Zeitschrift für Gastroenterologie. 40 (7): 497—502. PMID 12122597. doi:10.1055/s-2002-32805. CS1 održavanje: Format datuma (veza)
• Köhle C, Möhrle B, Münzel PA, Schwab M, Wernet D, Badary OA, Bock KW (maj 2003). „Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians”. Biochemical Pharmacology. 65 (9): 1521—7. PMID 12732365. doi:10.1016/S0006-2952(03)00074-1. CS1 održavanje: Format datuma (veza)
• Ockenga J, Vogel A, Teich N, Keim V, Manns MP, Strassburg CP (jun 2003). „UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer”. Gastroenterology. 124 (7): 1802—8. PMID 12806614. doi:10.1016/s0016-5085(03)00294-4 . CS1 održavanje: Format datuma (veza)