Mitogenom-aktivirana proteinska kinaza kinaza
Mitogenom-aktivirane proteinske kinaze kinaze (MAP2K) je enzim koji fosforiliše mitogenom-aktiviranu proteinsku kinazu (MAPK). MAP2K je klasifikovana kao EC 2.7.12.2.
| Mitogenom-aktivirana proteinska kinaza kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.12.2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Poznato je sedam gena:
- MAP2K1 (aka MEK1)
- MAP2K2 (aka MEK2)
- MAP2K3 (aka MKK3)
- MAP2K4 (aka MKK4)
- MAP2K5 (aka MKK5)
- MAP2K6 (aka MKK6)
- MAP2K7 (aka MKK7)
Aktivatori p38 (MKK3 i MKK6), JNK (MKK4 i MKK7), i ERK (MEK1 i MEK2) kinaza definišu nezavisne MAP kinazne puteve prenosa signala.[1][2]
Reference
uredi- ^ Dérijard B; et al. (1995). „Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms”. Science. 267 (5198): 682—5. PMID 7839144. doi:10.1126/science.7839144.
- ^ Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH (2001). „Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions”. Endocr. Rev. 22 (2): 153—83. PMID 11294822. doi:10.1210/er.22.2.153.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- Mitogen-Activated+Protein+Kinase+Kinases на US National Library of Medicine Medical Subject Headings (MeSH)
