JNJ 7777120
JNJ-7777120 je lek koji je razvila kompanija Džonson & Džonson. On deluje kao potentan i selektivan antagonist histaminskog H4 receptora.[1] On ima antiinflamatorno dejstvo.[2] Pokazano je da je superioran u odnosu na traditionalne antihistamine u treatmanu pruritusa (svraba).[3]
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| IUPAC ime | |
|---|---|
5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-indol | |
| Identifikatori | |
| CAS broj | 459168-41-3  |
| ATC kod | none |
| PubChem | CID 4908365 |
| IUPHAR/BPS | 1278 |
| ChEMBL | CHEMBL129198 |
| Sinonimi | 1-[(5-hloro-1H-indol-2-il)karbonil]-4-metilpiperazin |
| Hemijski podaci | |
| Formula | C14H16ClN3O |
| Molarna masa | 277,749 g/mol |
| |
Reference
uredi- ^ Jiang W; Lim, HD; Zhang M; et al. (2008). „Cloning and pharmacological characterization of the dog histamine H(4) receptor”. Eur. J. Pharmacol. 592 (1–3): 26—32. PMID 18639542. doi:10.1016/j.ejphar.2008.06.095.
- ^ Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Journal of Pharmacology and Experimental Therapeutics. 2004 Apr;309(1):404-13. PMID 14722321
- ^ Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. Journal of Allergy and Clinical Immunology. 2007 Jan;119(1):176-83. PMID 17208599
