Fluperlapin

Fluperlapin
IUPAC ime
	3-fluoro-6-(4-metilpiperazin-1-il)-11H-dibenzo[b,e]azepin
Identifikatori
CAS broj	67121-76-0
ATC kod	none
PubChem	CID 49381
ChemSpider	44882
UNII	EWG253M961
ChEMBL	CHEMBL63756
Hemijski podaci
Formula	C19H20FN3
Molarna masa	309,381 g/mol
	SMILES Fc4ccc3c(/N=C(/N1CCN(C)CC1)c2ccccc2C3)c4; ;
	InChI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3 ; Key:OBWGMKKHCLHVIE-UHFFFAOYSA-N ;

Fluperlapin (NB 106-689, fluoroperlapin) je triciklični atipični antipsihotik sa dodatnim antidepresivnim i sedativnim dejstvom. On je sintetisan 1979. Studiran je na životinjama i ljudima od 1984.^[1] Mada je pokazao efikasnost u tretmanu mnoštva oboljenja, uključujući šizofreniju,^[2]^[3]^[4]^[5] psihozu usled Parkinsonove bolest,^[6] depresiju, i distoniju,^[7] on nije plasiran na tržište.^[1]

Reference

^ ^а ^б Ganellin, C. R.; Triggle, D. J.; Macdonald, F. (1997). Dictionary of pharmacological agents. CRC Press. стр. 916. ISBN 978-0-412-46630-4. Приступљено 15. 9. 2011.
^ Fischer-Cornelssen, K. A. (1984). „Fluperlapine in 104 schizophrenic patients. Open multicenter trial”. Arzneimittel-Forschung. 34 (1A): 125—130. PMID 6145428.
^ Woggon, B.; Angst, J.; Bartels, M.; Heinrich, K.; Hippius, H.; Koukkou, M.; Krebs, E.; Küfferle, B.; Müller-Oerlinghausen, B. (1984). „Antipsychotic efficacy of fluperlapine. An open multicenter trial”. Neuropsychobiology. 11 (2): 116—120. PMID 6148712.
^ Dieterle, D.; Eben, E.; Einhäupl, K.; Hippius, H.; Klein, H.; Rüther, E.; Schmauß, M. (2008). „The Effect of Fluperlapine in Acute Psychotic Patients”. Pharmacopsychiatry. 17 (2): 57—60. PMID 6728910. doi:10.1055/s-2007-1017408.
^ Woggon, B.; Heinrich, K.; Küfferle, B.; Müller-Oerlinghausen, B.; Pöldinger, W.; Rüther, E.; Schied, H. W. (1984). „Results of a multicenter AMDP study with fluperlapine in schizophrenic patients”. Arzneimittel-Forschung. 34 (1A): 122—124. PMID 6145427.
^ Scholz, E.; Dichgans, J. (1985). „Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine”. European archives of psychiatry and neurological sciences. 235 (1): 60—64. PMID 2864254.
^ Pakkenberg, H.; Pedersen, B. (1985). „Medical treatment of dystonia”. Psychopharmacology. Supplementum. 2: 111—117. ISSN 0179-8456. OCLC 10642795. PMID 2860654.

Literatura

Ganellin, C. R.; Triggle, D. J.; Macdonald, F. (1997). Dictionary of pharmacological agents. CRC Press. стр. 916. ISBN 978-0-412-46630-4. Приступљено 15. 9. 2011.

Vidi još

Klozapin

Spoljašnje veze

[Ganellin-1] а ^б Ganellin, C. R.; Triggle, D. J.; Macdonald, F. (1997). Dictionary of pharmacological agents. CRC Press. стр. 916. ISBN 978-0-412-46630-4. Приступљено 15. 9. 2011.

[pmid6145428-2] Fischer-Cornelssen, K. A. (1984). „Fluperlapine in 104 schizophrenic patients. Open multicenter trial”. Arzneimittel-Forschung. 34 (1A): 125—130. PMID 6145428.

[pmid6148712-3] Woggon, B.; Angst, J.; Bartels, M.; Heinrich, K.; Hippius, H.; Koukkou, M.; Krebs, E.; Küfferle, B.; Müller-Oerlinghausen, B. (1984). „Antipsychotic efficacy of fluperlapine. An open multicenter trial”. Neuropsychobiology. 11 (2): 116—120. PMID 6148712.

[pmid6728910-4] Dieterle, D.; Eben, E.; Einhäupl, K.; Hippius, H.; Klein, H.; Rüther, E.; Schmauß, M. (2008). „The Effect of Fluperlapine in Acute Psychotic Patients”. Pharmacopsychiatry. 17 (2): 57—60. PMID 6728910. doi:10.1055/s-2007-1017408.

[pmid6145427-5] Woggon, B.; Heinrich, K.; Küfferle, B.; Müller-Oerlinghausen, B.; Pöldinger, W.; Rüther, E.; Schied, H. W. (1984). „Results of a multicenter AMDP study with fluperlapine in schizophrenic patients”. Arzneimittel-Forschung. 34 (1A): 122—124. PMID 6145427.

[pmid2864254-6] Scholz, E.; Dichgans, J. (1985). „Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine”. European archives of psychiatry and neurological sciences. 235 (1): 60—64. PMID 2864254.

[pmid2860654-7] Pakkenberg, H.; Pedersen, B. (1985). „Medical treatment of dystonia”. Psychopharmacology. Supplementum. 2: 111—117. ISSN 0179-8456. OCLC 10642795. PMID 2860654.

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