Feroksidaza
Feroksidaza (EC 1.16.3.1, ceruloplazmin, feroksidaza I, gvožđe oksidaza, gvožđe(II):kiseonik oksidoreduktaza, fero:O2 oksidoreduktaza, gvožđe II:kiseonik oksidoreduktaza, hefastin, HEPH) je enzim sa sistematskim imenom Fe(II):kiseonična oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Feroksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.16.3.1 | ||||||||
| CAS broj | 104404-69-5&title= 9031-37-2, 104404-69-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4 Fe(II) + 4 H+ + O2 4 Fe(III) + 2 H2O
Enzim u krvnoj plazmi (ceruloplazmin) pripada familiji multibakarnih oksidaza.
Reference
uredi- ^ Osaki, S. (1966). „Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)”. J. Biol. Chem. 241: 5053—5059. PMID 5925868.
- ^ Osaki, S. & Walaas, O. (1967). „Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex”. J. Biol. Chem. 242: 2653—2657. PMID 6027241.
- ^ Lindley, P.F. Card, G. Zaitseva, I. Zaitsev, V. Reinhammar, B. SelinLindgren, E. and Yoshida, K. (1997). „An X-ray structural study of human ceruloplasmin in relation to ferroxidase activity”. J. Biol. Inorg. Chem. 2: 454—463.
- ^ Takai, M., Kamimura, K. and Sugio, T. (2001). „A new iron oxidase from a moderately thermophilic iron oxidizing bacterium strain TI-1”. Eur. J. Biochem. 268: 1653—1658. PMID 11248684.
- ^ Chen, H., Attieh, Z.K., Su, T., Syed, B.A., Gao, H., Alaeddine, R.M., Fox, T.C., Usta, J., Naylor, C.E., Evans, R.W., McKie, A.T., Anderson, G.J. and Vulpe, C.D. (2004). „Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice”. Blood. 103: 3933—3939. PMID 14751926.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- Ferroxidase na US National Library of Medicine Medical Subject Headings (MeSH)
