Angiotensin-konvertujući enzim 2
Angiotensin-konvertujući enzim 2 (EC 3.4.17.23, ACE-2, ACE2, hACE2, angiotenzin konvertujući enzim 2, angiotenzin konvertujući enzim-2, Tmem27) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Angiotensin-konvertujući enzim 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.17.23 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- angiotenzin II + H2O angiotenzin-(1--7) + L-fenilalanin
Ovaj transmembranski glikoprotein sadrži ektracelularni katalitički domen.
Reference
uredi- ^ Vickers, C., Hales, P., Kaushik, V., Dick, L., Gavin, J., Tang, J., Godbout, K., Parsons, T., Baronas, E., Hsieh, F., Acton, S., Patane, M., Nichols, A. and Tummino, P. (2002). „Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase”. J. Biol. Chem. 277: 14838—14843. PMID 11815627.
- ^ Lambert, D.W., Hooper, N.M. and Turner, A.J. (2008). „Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system”. Biochem. Pharmacol. 75: 781—786. PMID 17897633.
- ^ Towler, P., Staker, B., Prasad, S.G., Menon, S., Tang, J., Parsons, T., Ryan, D., Fisher, M., Williams, D., Dales, N.A., Patane, M.A. and Pantoliano, M.W. (2004). „ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis”. J. Biol. Chem. 279: 17996—18007. PMID 14754895.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- Angiotensin-converting+enzyme+2 na US National Library of Medicine Medical Subject Headings (MeSH)
