ACPD

ACPD
Nazivi
	Sistemski IUPAC naziv 1-Aminociklopentan-1,3-dikarboksilna kiselina
Identifikacija
CAS broj	39026-63-6 ; 56827-69-1 (1R,3S); 111900-32-4 (1S,3R);
3D model (Jmol)	interaktivna slika;
Abrevijacija	ACPD
ChemSpider	5036967 (1S,3S) ; 201559 (1R,3R) ; 66220 (1R,3S) ; 94574 (1S,3R) ;
MeSH	1-amino-1,3-dicarboxycyclopentane
PubChem C ID	1310; 44381972 (1S); 231345 (1R,3R); 73537 (1R,3S); 104766 (1S,3R); 6604704 (1S,3S);
RTECS	GY4060000 (1S,3R)
	SMILES NC1(CCC(C1)C(O)=O)C(O)=O; ; ; ; ; ;
Svojstva
Hemijska formula	C7H11NO4
Molarna masa	173,17 g·mol−1
Agregatno stanje	Beli kristali
Rastvorljivost u vodi	20 g dm-3
Rastvorljivost u etanol	240 mg dm-3
log P	-0,709
Kiselost (pKa)	2,112
Baznost (pKb)	11,885
Izoelektrična tačka	2,84
Opasnosti
GHS grafikoni
GHS signalna reč	Warning
GHS opis opasnosti	H302, H312, H315, H319, H332, H335
GHS mere predostrožnosti	P261, P280, P305+351+338
EU klasifikacija (DSD)	Xn
R-oznake	R20/21/22, R36/37/38
S-oznake	S26, S36/37
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

1-Amino-1,3-dikarboksiciklopentan (ACPD) je hemijsko jedinjenje koje se vezuje za metabotropni glutamatni receptor (mGluR).^[4] ACPD deluje kao mGluR agonist. On je krut analog neurotransmitera glutamata koji ne aktivira jonotropne glutamatne receptore.^[5] ACPD može da indukuje konvulzije kod neonatalnih pacova.^[6]

Reference

^ „1-amino-1,3-dicarboxycyclopentane - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005. Identification and Related Records. Pristupljeno 15. 10. 2011.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. uredi
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Schoepp DD, True RA (1992). „1S,3R-ACPD-sensitive (metabotropic) [³H]glutamate receptor binding in membranes”. Neurosci. Lett. 145 (1): 100—4. PMID 1461560. doi:10.1016/0304-3940(92)90213-Q.
^ Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (1990). „(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes”. Mol. Pharmacol. 38 (1): 1—6. PMID 2164627.
^ McDonald JW, Fix AS, Tizzano JP, Schoepp DD (1993). „Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist”. J. Neurosci. 13 (10): 4445—55. PMID 8410197.