Википедија

Митогеном-активирана протеинска киназа 1

Mitogenom-aktivirana proteinska kinaza 1, takođe poznata kao MAPK1, p42MAPK, i ERK2, je enzim koji je kod ljudi kodiran MAPK1 genom.[1]

Mitogenom-aktivirana proteinska kinaza 1
PDB prikaz baziran na PDB: 1erk​.
Dostupne strukture
1erk​, 1gol​, 1pme​, 1tvo​, 1wzy​, 2erk​, 2fys​, 2gph​, 2ojg​, 2oji​, 2ojj​, 3erk​, 4erk​
Identifikatori
Simboli MAPK1; p38; ERK; p40; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p41; p41mapk
Vanjski ID OMIM: 176948 MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5594 26413
Ensembl ENSG00000100030 ENSMUSG00000063358
UniProt P28482 Q3UF82
RefSeq (mRNA) NM_002745 NM_001038663
RefSeq (protein) NP_002736 NP_001033752
Lokacija (UCSC) Chr 22:
20.45 - 20.55 Mb		 Chr 16:
16.9 - 16.96 Mb
PubMed pretraga [1] [2]

Funkcije

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Protein kodiran ovim genom je član familije MAP kinaza. Mitogenom-aktivirane proteinske kinaze, su takođe poznate kao ekstracelularnim signalom regulisane kinaze (ERK). One deluju kao tačka integracije višestrukih biohemijskih signala, i učestvuju u širokom varijetetu ćelijskih procesa kao što su proliferacija, diferencijacija, i regulacija transkripcije i razvoja. Prirekvizit aktivacije ove kinaze je njena fosforilisana uzvodnim kinazama. Nakon aktivacije, ova kinaza se translocira u jedro stimulisanih ćelija, gde ona fosforiliše proteine jedra. Dve alternativno splajsovane transkriptne varijante, koje se razlikuju u netranskribovanim regionima, kodiraju isti protein.[2]

Interakcije

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Za MAPK1 je bilo pokazano da interaguje sa TSC2,[3] PEA15,[4] DUSP1,[5][6] NEK2,[7] DUSP3,[8] STAT5A,[9][10] MAPK14,[11][12] FHL2,[13] TNIP1,[14] RPS6KA3,[15][16] RPS6KA2,[15][17] MAP2K1,[11][18][19][20][21][22] RPS6KA1,[16][17][23] PTPN7,[24][25] MKNK1,[26] CIITA,[27] TOB1,[28] Fosfatidiletanolamin vezujući protein 1,[19] DUSP22,[29] Myc,[30][31][32] ADAM17,[33] SORBS3,[34] ELK1,[23][35] VAV1,[36][37] HDAC4,[38] MKNK2,[26][39] MAP3K1[40] i UBR5.[23]

Vidi još

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Reference

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Literatura

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Spoljašnje veze

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