Гама-глутамилна хидролаза
Gama-glutamilna hidrolaza (EC 3.4.19.9, konjugaza, folatna konjugaza, lizozomalna gama-glutamilna karboksipeptidaza, gama-Glu-X karboksipeptidaza, pteroil-poli-gama-glutamatna hidrolaza, karboksipeptidaza G, folno kiselinska konjugaza, poli(gama-glutaminsko kiselinska) endohidrolaza, poliglutamatna hidrolaza, poli(glutaminsko kiselinska) hidrolaza II, pteroilpoli-gama-glutamilna hidrolaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Gama-glutamilna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.9 | ||||||||
| CAS broj | 9074-87-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Hidroliza gama-glutamilne veze
Ova lizozomalna ili izlučena, tiol-zavisna peptidaza je najaktivnija na kiselom pH.
Reference
уреди- ^ McGuire, J.J. & Coward, J.K. (1984). „Pteroylpolyglutamates: biosynthesis, degradation and function.”. Ур.: Blakley, R.L. and Benkovic, S.J. Folates and Pterins. New York: John Wiley and Sons. стр. 135—191.
- ^ Wang, Y., Nimec, Z., Ryan, T.J., Dias, J.A. and Galivan, J. (1993). „The properties of the secreted γ-glutamyl hydrolases from H35 hepatoma cells”. Biochim. Biophys. Acta. 1164: 227—235. PMID 8343522.
- ^ Yao, R., Rhee, M.S. and Galivan, J. (1995). „Effects of γ-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells”. Mol. Pharmacol. 48: 505—511. PMID 7565632.
- ^ Yao, R., Schneider, E., Ryan, T.J. and Galivan, J. (1996). „Human γ-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro”. Proc. Natl. Acad. Sci. USA. 93: 10134—10138. PMID 8816764.
- ^ Yao, R., Nimec, Z., Ryan, T.J. and Galivan, J. (1996). „Identification, cloning, and sequencing of a cDNA coding for rat γ-glutamyl hydrolase”. J. Biol. Chem. 271: 8525—8528. PMID 8621474.
Литература
уреди- McGuire, J.J. & Coward, J.K. (1984). „Pteroylpolyglutamates: biosynthesis, degradation and function.”. Ур.: Blakley, R.L. and Benkovic, S.J. Folates and Pterins. New York: John Wiley and Sons. стр. 135—191.
Spoljašnje veze
уреди- Gamma-glutamyl+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
