XRCC1

XRCC1
XRCC1
	PDB prikaz baziran na 1cdz.
Dostupne strukture
	1CDZ, 1XNA, 1XNT, 2D8M, 2W3O, 3K75, 3K77, 3LQC
Identifikatori
Simboli	XRCC1; RCC
Vanjski ID	OMIM: 194360 MGI: 99137 HomoloGene: 31368 GeneCards: XRCC1 Gene
Ontologija gena
Molekularna funkcija	• vezivanje za oštećenu DNK; • proteinsko vezivanje;
Celularna komponenta	• intracelularni; • nukleus; • nukleoplazma;
Biološki proces	• popravka jednolančanih prekida; • respons na hipoksiju; • DNK popravka; • popravka isecanjem baza; • respons na organske supstance; • respons na lek;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	7515
Ensembl	ENSG00000073050
UniProt	P18887
RefSeq (mRNA)	NM_006297.2
RefSeq (protein)	NP_006288.2
Lokacija (UCSC)	Chr 19:; 44.05 - 44.08 Mb
PubMed pretraga	[1]

XRCC1 je protein popravke DNK. On formira kompleks sa DNK ligazom III.

Ovaj protein učestvuje u popravci jednolančankih prekida DNK formiranih izlaganjem jonizujućoj radijaciji i alkilujućim agensima. Ovaj protein formira interakcije sa DNK ligazom III, polimerazom beta i poli ADP-riboznom polimerazom da bi učestvovao u putu popravke isecanjem baza. Moguće je da ima ulogu u DNK manipulacijama tokom mejoze i rekombinacije u ćelijama zametka. Retki mikrosatelitni polimorfizam ovog genu je vezan za pojavu pojedinih tipova kancera.^[1]

Interakcije

XRCC1 formira interakcije sa PARP2,^[2] DNK polimerazom beta,^[3]^[4]^[5]^[6] Aprataksinom,^[7]^[8] Oksoguaninskom glikosilaza,^[9] PCNA,^[4] APEX1,^[10] PNKP^[11]^[12] i PARP1.^[8]^[13]

Reference

^ „Entrez Gene: XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1”.
^ Schreiber, Valérie; et al. (2002). „Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1”. J. Biol. Chem. United States. 277 (25): 23028—36. ISSN 0021-9258. PMID 11948190. doi:10.1074/jbc.M202390200.
^ Wang, Liming; et al. (2004). „A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype”. Cancer Res. United States. 64 (21): 7673—7. ISSN 0008-5472. PMID 15520167. doi:10.1158/0008-5472.CAN-04-2801.
^ ^а ^б Fan, Jinshui; et al. (2004). „XRCC1 co-localizes and physically interacts with PCNA”. Nucleic Acids Res. England. 32 (7): 2193—201. PMC 407833  . PMID 15107487. doi:10.1093/nar/gkh556.
^ Kubota, Y; et al. (1996). „Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein”. EMBO J. ENGLAND. 15 (23): 6662—70. ISSN 0261-4189. PMC 452490  . PMID 8978692.
^ Bhattacharyya, N; S, Banerjee (2001). „A novel role of XRCC1 in the functions of a DNA polymerase beta variant”. Biochemistry. United States. 40 (30): 9005—13. ISSN 0006-2960. PMID 11467963. doi:10.1021/bi0028789.
^ Date, Hidetoshi; et al. (2004). „The FHA domain of aprataxin interacts with the C-terminal region of XRCC1”. Biochem. Biophys. Res. Commun. United States. 325 (4): 1279—85. ISSN 0006-291X. PMID 15555565. doi:10.1016/j.bbrc.2004.10.162.
^ ^а ^б Gueven, Nuri; et al. (2004). „Aprataxin, a novel protein that protects against genotoxic stress”. Hum. Mol. Genet. England. 13 (10): 1081—93. ISSN 0964-6906. PMID 15044383. doi:10.1093/hmg/ddh122.
^ Marsin, Stéphanie; et al. (2003). „Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1”. J. Biol. Chem. United States. 278 (45): 44068—74. ISSN 0021-9258. PMID 12933815. doi:10.1074/jbc.M306160200.
^ Vidal, A E; et al. (2001). „XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions”. EMBO J. England. 20 (22): 6530—9. ISSN 0261-4189. PMC 125722  . PMID 11707423. doi:10.1093/emboj/20.22.6530.
^ Whitehouse, C J; et al. (2001). „XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair”. Cell. United States. 104 (1): 107—17. ISSN 0092-8674. PMID 11163244. doi:10.1016/S0092-8674(01)00195-7.
^ Ewing, Rob M; et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. England. 3 (1): 89. PMC 1847948  . PMID 17353931. doi:10.1038/msb4100134.
^ Masson, M; et al. (1998). „XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage”. Mol. Cell. Biol. UNITED STATES. 18 (6): 3563—71. ISSN 0270-7306. PMC 108937  . PMID 9584196.

Literatura

Hung RJ, Hall J, Brennan P, Boffetta P (2006). „Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.”. Am. J. Epidemiol. 162 (10): 925—42. PMID 16221808. doi:10.1093/aje/kwi318.
LH, Thompson; Brookman KW; NJ, Jones; et al. (1991). „Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.”. Mol. Cell. Biol. 10 (12): 6160—71. PMC 362891  . PMID 2247054.
LH, Thompson; Bachinski LL; RL, Stallings; et al. (1990). „Complementation of repair gene mutations on the hemizygous chromosome 9 in CHO: a third repair gene on human chromosome 19.”. Genomics. 5 (4): 670—9. PMID 2591959. doi:10.1016/0888-7543(89)90107-9.
G, Gyapay; Morissette J; A, Vignal; et al. (1994). „The 1993-94 Généthon human genetic linkage map.”. Nat. Genet. 7 (2 Spec No): 246—339. PMID 7545953. doi:10.1038/ng0694supp-246.
Q, Wei; Xu X; L, Cheng; et al. (1995). „Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR.”. Cancer Res. 55 (21): 5025—9. PMID 7585546.
JE, Lamerdin; Montgomery MA; SA, Stilwagen; et al. (1995). „Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions.”. Genomics. 25 (2): 547—54. PMID 7789989. doi:10.1016/0888-7543(95)80056-R.
KW, Caldecott; McKeown CK; JD, Tucker; et al. (1994). „An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.”. Mol. Cell. Biol. 14 (1): 68—76. PMC 358357  . PMID 8264637.
B, Trask; Fertitta A; M, Christensen; et al. (1993). „Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.”. Genomics. 15 (1): 133—45. PMID 8432525. doi:10.1006/geno.1993.1021.
Y, Kubota; Nash RA; A, Klungland; et al. (1997). „Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.”. EMBO J. 15 (23): 6662—70. PMC 452490  . PMID 8978692.
Nash RA, Caldecott KW, Barnes DE, Lindahl T (1997). „XRCC1 protein interacts with one of two distinct forms of DNA ligase III.”. Biochemistry. 36 (17): 5207—11. PMID 9136882. doi:10.1021/bi962281m.
Shen MR, Jones IM, Mohrenweiser H (1998). „Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.”. Cancer Res. 58 (4): 604—8. PMID 9485007.
EA, Price; Bourne SL; R, Radbourne; et al. (1998). „Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity.”. Somat. Cell Mol. Genet. 23 (4): 237—47. PMID 9542526. doi:10.1007/BF02674415.
M, Masson; Niedergang C; V, Schreiber; et al. (1998). „XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage.”. Mol. Cell. Biol. 18 (6): 3563—71. PMC 108937  . PMID 9584196.
Taylor RM, Wickstead B, Cronin S, Caldecott KW (1998). „Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1.”. Curr. Biol. 8 (15): 877—80. PMID 9705932. doi:10.1016/S0960-9822(07)00350-8.
Zhou ZQ, Walter CA (1998). „Cloning and characterization of the promoter of baboon XRCC1, a gene involved in DNA strand-break repair.”. Somat. Cell Mol. Genet. 24 (1): 23—39. PMID 9776979. doi:10.1007/BF02677493.
RM, Taylor; Moore DJ; J, Whitehouse; et al. (2000). „A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair.”. Mol. Cell. Biol. 20 (2): 735—40. PMC 85188  . PMID 10611252. doi:10.1128/MCB.20.2.735-740.2000.
A, Marintchev; Robertson A; EK, Dimitriadis; et al. (2000). „Domain specific interaction in the XRCC1-DNA polymerase beta complex.”. Nucleic Acids Res. 28 (10): 2049—59. PMC 105377  . PMID 10773072. doi:10.1093/nar/28.10.2049.
EJ, Duell; Wiencke JK; TJ, Cheng; et al. (2000). „Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.”. Carcinogenesis. 21 (5): 965—71. PMID 10783319. doi:10.1093/carcin/21.5.965.
CJ, Whitehouse; Taylor RM; A, Thistlethwaite; et al. (2001). „XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.”. Cell. 104 (1): 107—17. PMID 11163244. doi:10.1016/S0092-8674(01)00195-7.
A, Dulic; Bates PA; X, Zhang; et al. (2001). „BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III.”. Biochemistry. 40 (20): 5906—13. PMID 11352725. doi:10.1021/bi002701e.

Spoljašnje veze

X-ray+repair+cross+complementing+protein+1 на US National Library of Medicine Medical Subject Headings (MeSH)

[1] „Entrez Gene: XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1”.

[pmid11948190-2] Schreiber, Valérie; et al. (2002). „Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1”. J. Biol. Chem. United States. 277 (25): 23028—36. ISSN 0021-9258. PMID 11948190. doi:10.1074/jbc.M202390200.

[pmid15520167-3] Wang, Liming; et al. (2004). „A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype”. Cancer Res. United States. 64 (21): 7673—7. ISSN 0008-5472. PMID 15520167. doi:10.1158/0008-5472.CAN-04-2801.

[pmid15107487-4] а ^б Fan, Jinshui; et al. (2004). „XRCC1 co-localizes and physically interacts with PCNA”. Nucleic Acids Res. England. 32 (7): 2193—201. PMC 407833  . PMID 15107487. doi:10.1093/nar/gkh556.

[pmid8978692-5] Kubota, Y; et al. (1996). „Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein”. EMBO J. ENGLAND. 15 (23): 6662—70. ISSN 0261-4189. PMC 452490  . PMID 8978692.

[pmid11467963-6] Bhattacharyya, N; S, Banerjee (2001). „A novel role of XRCC1 in the functions of a DNA polymerase beta variant”. Biochemistry. United States. 40 (30): 9005—13. ISSN 0006-2960. PMID 11467963. doi:10.1021/bi0028789.

[pmid15555565-7] Date, Hidetoshi; et al. (2004). „The FHA domain of aprataxin interacts with the C-terminal region of XRCC1”. Biochem. Biophys. Res. Commun. United States. 325 (4): 1279—85. ISSN 0006-291X. PMID 15555565. doi:10.1016/j.bbrc.2004.10.162.

[pmid15044383-8] а ^б Gueven, Nuri; et al. (2004). „Aprataxin, a novel protein that protects against genotoxic stress”. Hum. Mol. Genet. England. 13 (10): 1081—93. ISSN 0964-6906. PMID 15044383. doi:10.1093/hmg/ddh122.

[pmid12933815-9] Marsin, Stéphanie; et al. (2003). „Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1”. J. Biol. Chem. United States. 278 (45): 44068—74. ISSN 0021-9258. PMID 12933815. doi:10.1074/jbc.M306160200.

[pmid11707423-10] Vidal, A E; et al. (2001). „XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions”. EMBO J. England. 20 (22): 6530—9. ISSN 0261-4189. PMC 125722  . PMID 11707423. doi:10.1093/emboj/20.22.6530.

[pmid11163244-11] Whitehouse, C J; et al. (2001). „XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair”. Cell. United States. 104 (1): 107—17. ISSN 0092-8674. PMID 11163244. doi:10.1016/S0092-8674(01)00195-7.

[pmid17353931-12] Ewing, Rob M; et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. England. 3 (1): 89. PMC 1847948  . PMID 17353931. doi:10.1038/msb4100134.

[pmid9584196-13] Masson, M; et al. (1998). „XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage”. Mol. Cell. Biol. UNITED STATES. 18 (6): 3563—71. ISSN 0270-7306. PMC 108937  . PMID 9584196.

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