Vaskularni endotelni faktor rasta

Vaskularni endotelni faktor rasta (VEGF) je signalni protein.^[1]^[2]^[3] Njega proizvode ćelije koje stimulišu vaskulogenezu i angiogenezu. On je deo sistema koji obnavlja snabdevanje kiseoniom tkiva kad je cirkulacija krvi neadekvatna.

Serumska koncentracija VEGF-a je visoka kod Bronhijalne astme i niska kod dijabetesa. VEGF-ova normalna funkcija je kreiranje novih krvnih sudova tokom embrionskog razvoja, novih krvnih sudova nakon povrede, mišića nakon vežbanja, i novih sudova (kolateralna cirkulacija) za zaobilaženje blokiranih sudova.

Kad je VEGF prekomerno izražen, on može da doprinese bolesti. Čvrsti kanceri ne mogu da rastu izvan ograničene veličine bez adekvatnog pristupa krvi. Kanceri koji izražavaju VEGF imaju sposobnost rasta i metastaze. Prekomerno izražavanje VEGF-a može da uzrokuje vaskularno oboljenje retine oka i drugih delova tela. Lekovi, kao što je bevacizumab, mogu da inhibiraju VEGF i da kontrolišu ili usporavaju razvoj tih bolesti.

VEGF je potfamilija faktora rasta, specifično familije faktora rasta izvedenih iz trombocita. Oni su važni signalni proteini koji učestvuju u vaskulogenezi (de novo formiranju embrionskog krvnog sistema) i angiogenezi (rastu krvnih sudova iz postojeće mreže).

Reference

^ Daekyu Sun, Kexiao Guo, Jadrian J. Rusche and Laurence H. Hurley. „Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents”. Nucleic Acids Research. 33 (18): 6070—6080. doi:10.1093/nar/gki917.
^ Himesh Fernando; Anthony P. Reszka; Julian Huppert; Sylvain Ladame; Sarah Rankin; Ashok R. Venkitaraman; Stephen Neidle & Shankar Balasubramanian (2006). „A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene”. Biochemistry. 45 (25): 7854—7860. doi:10.1021/bi0601510.
^ Daekyu Sun, Wei-Jun Liu, Kexiao Guo, Jadrian J. Rusche, Scot Ebbinghaus, Vijay Gokhale and Laurence H. Hurley. „The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents”. Mol Cancer Ther April. 2008 (7): 880. doi:10.1158/1535-7163.MCT-07-2119.

Literatura

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Spoljašnje veze

Vascular+Endothelial+Growth+Factors на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Daekyu Sun, Kexiao Guo, Jadrian J. Rusche and Laurence H. Hurley. „Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents”. Nucleic Acids Research. 33 (18): 6070—6080. doi:10.1093/nar/gki917.

[2] Himesh Fernando; Anthony P. Reszka; Julian Huppert; Sylvain Ladame; Sarah Rankin; Ashok R. Venkitaraman; Stephen Neidle & Shankar Balasubramanian (2006). „A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene”. Biochemistry. 45 (25): 7854—7860. doi:10.1021/bi0601510.

[3] Daekyu Sun, Wei-Jun Liu, Kexiao Guo, Jadrian J. Rusche, Scot Ebbinghaus, Vijay Gokhale and Laurence H. Hurley. „The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents”. Mol Cancer Ther April. 2008 (7): 880. doi:10.1158/1535-7163.MCT-07-2119.

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