Urokanatna hidrataza
Urokanatna hidrataza (EC 4.2.1.49, urokanaza, 3-(5-okso-4,5-dihidro-3H-imidazol-4-il)propanoat hidrolijaza) je enzim sa sistematskim imenom 3-(5-okso-4,5-dihidro-3H-imidazol-4-il)propanoat hidrolijaza (formira urokanat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Urokanatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.2.1.49 | ||||||||
| CAS broj | 9014-58-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 3-(5-okso-4,5-dihidro-3H-imidazol-4-il)propanoat urokanat + H2O
Ovaj enzim sadrži čvrsto vezani NAD+.
Reference
уреди- ^ Rétey, J. (1994). „The urocanase story: a novel role of NAD+ as electrophile”. Arch. Biochem. Biophys. 314: 1—16. PMID 7944380.
- ^ Hassall, H. & Greenberg, D.M. (1971). „Urocanase (beef liver)”. Methods Enzymol. 17B: 84—88.
- ^ Kaminskas, E., Kimhi, Y. and Magasanik, B. (1970). „Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway”. J. Biol. Chem. 245: 3536—3544. PMID 4990470.
- ^ Swaine, D. (1969). „The effect of substrate analogues on the activity of cat liver urocanase”. Biochim. Biophys. Acta. 178: 609—618. PMID 5784906.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Urocanate+hydratase на US National Library of Medicine Medical Subject Headings (MeSH)
