UGT2A1

UGT2A1
Identifikatori
Alijasi	UGT2A1
Spoljašnji ID	OMIM: 604716 MGI: 2149905 HomoloGene: 136808 GeneCards: UGT2A1
Genska lokacija (miš)
Hr.	Chromosome 5 (mouse)
Kraj	87,638,730 bp
Genska ontologija
Molecular function	• glycosyltransferase activity; • transferase activity; • glucuronosyltransferase activity; • hexosyltransferase activity; • UDP-glycosyltransferase activity;
Cellular component	• саставни део мембране; • intracellular membrane-bounded organelle; • мембрана;
Biological process	• sensory perception of smell; • detection of chemical stimulus; • Glukuronidacija; • одговор на надражај; • метаболизам;
	Sources:Amigo / QuickGO
Ortolozi
	10941
	94215
	ENSG00000173610
	ENSMUSG00000106677
	Q9Y4X1
	Q80X89
	NM_001252274; NM_001252275; NM_001301239; NM_006798; NM_001389565
	NM_053184
NP_001099147; NP_001288162; NP_001239203; NP_001239204; NP_001288168;
	NP_006789
	NP_444414
	Wikidata
View/Edit Human	View/Edit Mouse

UDP glukuronoziltransferaza 2 familija, polipeptid B1, takođe poznata kao UGT2B1, je enzim koji je kod ljudi kodiran genom UGT2B1.^[4]^[5]

Funkcija

Olfaktorni neuroepitel, koji oblaže zadnji deo nosne šupljine, izložen je širokom spektru mirisa i toksičnih jedinjenja u vazduhu. Odoranti, koji su uglavnom mali lipofilni molekuli, ulaze u tok sluzi i dospevaju do receptora mirisa na senzornim neuronima. Osećaj mirisa je generalno prolazan proces, koji zahteva efikasan završetak signala, koji se može obezbediti biotransformacijom mirisa u ćelijama koje podržavaju epitel. Smatra se da enzimi koji metabolišu ksenobiotike u olfaktornom epitelu katalizuju inaktivaciju i olakšavaju eliminaciju mirisa.^[5] Nedavno je utvrđeno da UGT2A1 i UGT2A2 imaju ulogu u gubitku osećaja mirisa povezanom sa COVID-19.^[6]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000106677 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jedlitschky G, Cassidy AJ, Sales M, Pratt N, Burchell B (јун 1999). „Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase”. Biochem. J. 340 (3): 837—43. PMC 1220318  . PMID 10359671. doi:10.1042/0264-6021:3400837.
^ ^а ^б „Entrez Gene: UGT2B1 UDP glucuronosyltransferase 2 family, polypeptide B1”.
^ Shelton, Janie F.; Shastri, Anjali J.; Aslibekyan, Stella; Auton, Adam; Auton, Adam (2021). The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia.

Literatura

Iida A, Saito S, Sekine A, et al. (2002). „Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.”. J. Hum. Genet. 47 (10): 505—10. PMID 12376738. doi:10.1007/s100380200075  .
Tukey RH, Strassburg CP (2001). „Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract.”. Mol. Pharmacol. 59 (3): 405—14. PMID 11179432. S2CID 21500183. doi:10.1124/mol.59.3.405.
Strassburg CP, Kneip S, Topp J, et al. (2000). „Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.”. J. Biol. Chem. 275 (46): 36164—71. PMID 10748067. doi:10.1074/jbc.M002180200  .
Heydel J, Leclerc S, Bernard P, et al. (2001). „Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis.”. Brain Res. Mol. Brain Res. 90 (1): 83—92. PMID 11376859. doi:10.1016/S0169-328X(01)00080-8.
Saito A, Kawamoto M, Kamatani N (2009). „Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.”. J. Hum. Genet. 54 (6): 317—23. PMID 19343046. doi:10.1038/jhg.2009.31  .
Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). „Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.”. Nat. Genet. 41 (12): 1345—9. PMID 19898482. S2CID 21293339. doi:10.1038/ng.478.
Mackenzie PI, Bock KW, Burchell B, et al. (2005). „Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.”. Pharmacogenet. Genomics. 15 (10): 677—85. PMID 16141793. doi:10.1097/01.fpc.0000173483.13689.56.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000106677 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10359671-4] Jedlitschky G, Cassidy AJ, Sales M, Pratt N, Burchell B (јун 1999). „Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase”. Biochem. J. 340 (3): 837—43. PMC 1220318  . PMID 10359671. doi:10.1042/0264-6021:3400837.

[entrez-5] а ^б „Entrez Gene: UGT2B1 UDP glucuronosyltransferase 2 family, polypeptide B1”.

[6] Shelton, Janie F.; Shastri, Anjali J.; Aslibekyan, Stella; Auton, Adam; Auton, Adam (2021). The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia.

[4]

[5]

[1]

[2]

[3]

[6]