Timopoietin

Timopoietin
Timopoietin
	PDB prikaz baziran na 1gjj.
Dostupne strukture
	1GJJ, 1H9E, 1H9F
Identifikatori
Simboli	TMPO; CMD1T; LAP2; LEMD4; PRO0868; TP
Vanjski ID	OMIM: 188380 MGI: 106920 HomoloGene: 31144 GeneCards: TMPO Gene
Ontologija gena
Molekularna funkcija	• DNK vezivanje; • proteinsko vezivanje; • laminsko vezivanje;
Celularna komponenta	• hromatin; • jedro; • unutrašnja membrana jedra;
Biološki proces	• regulacija transkripcije, DNK-zavisna;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	7112
Ensembl	ENSG00000120802
UniProt	P42166
RefSeq (mRNA)	NM_001032283.2
RefSeq (protein)	NP_001027454.1
Lokacija (UCSC)	Chr 12:; 98.91 - 98.94 Mb
PubMed pretraga	[1]

Timopoietin (polipeptid vezan za laminu 2, LAP2) je protein koji je kod ljudi kodiran TMPO genom.^[1]^[2] LAP2 je protein unutrašnje membrane jedra.^[3]

Timopoietin učestvuje u indukciji CD90 proteina u grudnu žlezdu. Gen timopoetina kodira tri alternativno splajsovane iRNK molekula koji kodiraju proteine sa 75 kDa (alfa), 51 kDa (beta) i 39 kDa (gama). Oni su izraženi u većini ćelijskih tipova. Ljudski TMPO gen se nalazi u hromozomsko opsegu 12q22 i sastoji se od osam eksona.

Interakcije

Timopoietin formira interakcije sa barijerom za autointegracioni faktor 1,^[4] AKAP8L,^[5]^[6] LMNB1^[7]^[8] i LMNA.^[9]^[10]

Reference

^ Harris CA, Andryuk PJ, Cline S, Chan HK, Natarajan A, Siekierka JJ, Goldstein G (1994). „Three distinct human thymopoietins are derived from alternatively spliced mRNAs”. Proc Natl Acad Sci U S A. 91 (14): 6283—7. PMC 44185  . PMID 7517549. doi:10.1073/pnas.91.14.6283.
^ „Entrez Gene: TMPO thymopoietin”.
^ „Inner nuclear membrane proteins: functions and targeting”. PMID 11766875.
^ Furukawa, K (1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction”. J. Cell. Sci. ENGLAND. 112 (15): 2485—92. ISSN 0021-9533. PMID 10393804.
^ Martins, S B; T, Eide; et al. (2000). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics”. J. Cell. Sci. ENGLAND. 113 (21): 3703—13. ISSN 0021-9533. PMID 11034899.
^ Martins, Sandra; Sissel, Eikvar; et al. (2003). „HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication”. J. Cell Biol. United States. 160 (2): 177—88. ISSN 0021-9525. PMC 2172640  . PMID 12538639. doi:10.1083/jcb.200210026.
^ Furukawa, K; T, Kondo (1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin”. Eur. J. Biochem. GERMANY. 251 (3): 729—33. ISSN 0014-2956. PMID 9490046. doi:10.1046/j.1432-1327.1998.2510729.x.
^ Foisner, R; L, Gerace (1993). „Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation”. Cell. UNITED STATES. 73 (7): 1267—79. ISSN 0092-8674. PMID 8324822. doi:10.1016/0092-8674(93)90355-T.
^ Markiewicz, Ewa; Thomas, Dechat; et al. (2002). „Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein”. Mol. Biol. Cell. United States. 13 (12): 4401—13. ISSN 1059-1524. PMC 138642  . PMID 12475961. doi:10.1091/mbc.E02-07-0450.
^ Dechat, T; B, Korbei; et al. (2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins”. J. Cell. Sci. ENGLAND. 113 (19): 3473—84. ISSN 0021-9533. PMID 10984438.

Literatura

Harris CA, Andryuk PJ, Cline SW, Mathew S, Siekierka JJ, Goldstein G (1995). „Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2”. Genomics. 28 (2): 198—205. PMID 8530026. doi:10.1006/geno.1995.1131.
Dechat T, Vlcek S, Foisner R (2000). „Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics.”. J. Struct. Biol. 129 (2-3): 335—45. PMID 10806084. doi:10.1006/jsbi.2000.4212.
JJ, Twomey; G, Goldstein; VM, Lewis; et al. (1977). „Bioassay determinations of thymopoietin and thymic hormone levels in human plasma.”. Proc. Natl. Acad. Sci. U.S.A. 74 (6): 2541—5. PMC 432209  . PMID 302007. doi:10.1073/pnas.74.6.2541.
Heavner GA, Audhya T, Goldstein G (1990). „Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines.”. Regul. Pept. 27 (2): 257—62. PMID 2158125. doi:10.1016/0167-0115(90)90044-W.
Fuccello A, Audhya T, Talle MA, Goldstein G (1984). „Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies.”. Arch. Biochem. Biophys. 228 (1): 292—8. PMID 6364989. doi:10.1016/0003-9861(84)90070-5.
H, Hara; K, Hayashi; K, Ohta; et al. (1995). „A new thymopoietin precursor gene from human thymus.”. Biochem. Mol. Biol. Int. 34 (5): 927—33. PMID 7703909.
Goldstein G, Schlesinger DH, Audhya T (1994). „Isolation and complete amino acid sequence of human thymopoietin and splenin.”. Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6249. PMC 44176  . PMID 8016147. doi:10.1073/pnas.91.13.6249.
CA, Harris; PJ, Andryuk; SW, Cline; et al. (1996). „Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2.”. Genomics. 28 (2): 198—205. PMID 8530026. doi:10.1006/geno.1995.1131.
B, Andersson; MA, Wentland; JY, Ricafrente; et al. (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138.
R, Berger; L, Theodor; J, Shoham; et al. (1996). „The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products.”. Genome Res. 6 (5): 361—70. PMID 8743987. doi:10.1101/gr.6.5.361.
W, Yu; B, Andersson; KC, Worley; et al. (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353—8. PMC 139146  . PMID 9110174. doi:10.1101/gr.7.4.353.
Furukawa K, Fritze CE, Gerace L (1998). „The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain.”. J. Biol. Chem. 273 (7): 4213—9. PMID 9461618. doi:10.1074/jbc.273.7.4213.
Furukawa K, Kondo T (1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin.”. Eur. J. Biochem. 251 (3): 729—33. PMID 9490046. doi:10.1046/j.1432-1327.1998.2510729.x.
T, Dechat; J, Gotzmann; A, Stockinger; et al. (1998). „Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics.”. EMBO J. 17 (16): 4887—902. PMC 1170818  . PMID 9707448. doi:10.1093/emboj/17.16.4887.
K, Furukawa (1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction.”. J. Cell. Sci. 112 (15): 2485—92. PMID 10393804.
PJ, Weber; CP, Eckhard; S, Gonser; et al. (1999). „On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family.”. Biol. Chem. 380 (6): 653—60. PMID 10430029. doi:10.1515/BC.1999.081.
T, Dechat; B, Korbei; OA, Vaughan; et al. (2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins.”. J. Cell. Sci. 113 (19): 3473—84. PMID 10984438.
SB, Martins; T, Eide; RL, Steen; et al. (2001). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics.”. J. Cell. Sci. 113 (21): 3703—13. PMID 11034899.

Spoljašnje veze

Thymopoietins на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid7517549-1] Harris CA, Andryuk PJ, Cline S, Chan HK, Natarajan A, Siekierka JJ, Goldstein G (1994). „Three distinct human thymopoietins are derived from alternatively spliced mRNAs”. Proc Natl Acad Sci U S A. 91 (14): 6283—7. PMC 44185  . PMID 7517549. doi:10.1073/pnas.91.14.6283.

[entrez-2] „Entrez Gene: TMPO thymopoietin”.

[Worman-3] „Inner nuclear membrane proteins: functions and targeting”. PMID 11766875.

[pmid10393804-4] Furukawa, K (1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction”. J. Cell. Sci. ENGLAND. 112 (15): 2485—92. ISSN 0021-9533. PMID 10393804.

[pmid11034899-5] Martins, S B; T, Eide; et al. (2000). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics”. J. Cell. Sci. ENGLAND. 113 (21): 3703—13. ISSN 0021-9533. PMID 11034899.

[pmid12538639-6] Martins, Sandra; Sissel, Eikvar; et al. (2003). „HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication”. J. Cell Biol. United States. 160 (2): 177—88. ISSN 0021-9525. PMC 2172640  . PMID 12538639. doi:10.1083/jcb.200210026.

[pmid9490046-7] Furukawa, K; T, Kondo (1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin”. Eur. J. Biochem. GERMANY. 251 (3): 729—33. ISSN 0014-2956. PMID 9490046. doi:10.1046/j.1432-1327.1998.2510729.x.

[pmid8324822-8] Foisner, R; L, Gerace (1993). „Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation”. Cell. UNITED STATES. 73 (7): 1267—79. ISSN 0092-8674. PMID 8324822. doi:10.1016/0092-8674(93)90355-T.

[pmid12475961-9] Markiewicz, Ewa; Thomas, Dechat; et al. (2002). „Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein”. Mol. Biol. Cell. United States. 13 (12): 4401—13. ISSN 1059-1524. PMC 138642  . PMID 12475961. doi:10.1091/mbc.E02-07-0450.

[pmid10984438-10] Dechat, T; B, Korbei; et al. (2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins”. J. Cell. Sci. ENGLAND. 113 (19): 3473—84. ISSN 0021-9533. PMID 10984438.

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