SB-742,457
SB-742,457 je selektivni antagonist 5-HT6 receptora sa uticajem na kogniciju, memoriju, i učenje.[1][2][3][4] On je u razvoju za tretman Alchajmerove bolesti i preliminarno je pokazano da je efikasan u kliničkim ispitivanjima faze II.[3][4][5]
 | |
| IUPAC ime | |
|---|---|
3-fenilsulfonil-8-(piperazin-1-il)hinolin | |
| Klinički podaci | |
| Način primene | Oralno |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| CAS broj | 607742-69-8  |
| ATC kod | none |
| PubChem | CID 11256720 |
| ChEMBL | CHEMBL1083390 |
| Hemijski podaci | |
| Formula | C19H19N3O2S |
| Molarna masa | 353,44 g/mol |
| |
Reference
уреди- ^ Upton N, Chuang TT, Hunter AJ, Virley DJ (2008). „5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease”. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. 5 (3): 458—69. PMID 18625457. doi:10.1016/j.nurt.2008.05.008.
- ^ Idris N; Neill J; Grayson B; et al. (2010). „Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms”. Psychopharmacology. 208 (1): 23—36. PMID 19851757. doi:10.1007/s00213-009-1702-5.
- ^ а б Maher-Edwards G; Zvartau-Hind M; Hunter AJ; et al. (2009). „Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimer's Disease”. Current Alzheimer Research. 7 (5): 374—85. PMID 20043816. Архивирано из оригинала 06. 10. 2011. г. Приступљено 12. 12. 2012.
- ^ а б Rossé G, Schaffhauser H (2010). „5-HT(6) Receptor Antagonists as Potential Therapeutics for Cognitive Impairment”. Current Topics in Medicinal Chemistry. 10 (2): 207—21. PMID 20166958. doi:10.2174/156802610790411036. Архивирано из оригинала 06. 10. 2011. г. Приступљено 12. 12. 2012.
- ^ „Search of: SB-742457 - List Results - ClinicalTrials.gov”.
