SB-258,585

SB-258,585
IUPAC ime
	4-Jodo-N-[4-metoksi-3-(4-metil-1-piperazinil)fenil]benzensulfonamid
Identifikatori
CAS broj	209480-63-7
ATC kod	none
PubChem	CID 3248571
ChEMBL	CHEMBL60264
Hemijski podaci
Formula	C18H22IN3O3S
Molarna masa	487,354 g/mol
	SMILES C3CN(C)CCN3c1cc(ccc1OC)NS(=O)(=O)c2ccc(I)cc2; ;

SB-258,585 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan, selektivan i oralno aktivan antagonist 5-HT₆ receptora, sa Ki od 8,9 nM.^[1] On se koristi u obliku ¹²⁵I radio obeleženoj formi za maporamke distribucije 5-HT₆ receptora u mozgu.^[2]^[3]

Reference

^ Hirst, WD; Minton, JA; Bromidge, SM; Moss, SF; Latter, AJ; Riley, G; Routledge, C; Middlemiss, DN; Price, GW (2000). „Characterization of 125I-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue”. British Journal of Pharmacology. 130 (7): 1597—605. PMC 1572217  . PMID 10928963. doi:10.1038/sj.bjp.0703458.
^ Roberts, JC; Reavill, C; East, SZ; Harrison, PJ; Patel, S; Routledge, C; Leslie, RA (2002). „The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist (125)ISB-258585”. Brain Research. 934 (1): 49—57. PMID 11937069. doi:10.1016/S0006-8993(02)02360-0.
^ East, SZ; Burnet, PW; Leslie, RA; Roberts, JC; Harrison, PJ (2002). „5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with 125ISB-258585”. Synapse. 45 (3): 191—9. PMID 12112397. doi:10.1002/syn.10097.

Spoljašnje veze

[1] Hirst, WD; Minton, JA; Bromidge, SM; Moss, SF; Latter, AJ; Riley, G; Routledge, C; Middlemiss, DN; Price, GW (2000). „Characterization of 125I-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue”. British Journal of Pharmacology. 130 (7): 1597—605. PMC 1572217  . PMID 10928963. doi:10.1038/sj.bjp.0703458.

[2] Roberts, JC; Reavill, C; East, SZ; Harrison, PJ; Patel, S; Routledge, C; Leslie, RA (2002). „The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist (125)ISB-258585”. Brain Research. 934 (1): 49—57. PMID 11937069. doi:10.1016/S0006-8993(02)02360-0.

[3] East, SZ; Burnet, PW; Leslie, RA; Roberts, JC; Harrison, PJ (2002). „5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with 125ISB-258585”. Synapse. 45 (3): 191—9. PMID 12112397. doi:10.1002/syn.10097.

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