Ro60-0175
Ro60-0175 je lek koji je razvila kompanija Hoffmann–La Roche. On se primenjuje u naučnim istraživanjima.[1][2] Ro60-0175 je potentan i selektivan agonist 5-HT2B i 5-HT2C serotoninskih receptorskih tipova, sa dobrom selektivnošću u odnosu na srodni 5-HT2A tip, i neznatnim afinitetom za druge receptore.[3][4]
 | |
| IUPAC ime | |
|---|---|
(S)-6-Chloro-5-fluoro-1H-indole-2-propanamine | |
| Identifikatori | |
| CAS broj | 169675-09-6  |
| PubChem | CID 5312145 |
| Hemijski podaci | |
| Formula | C11H12ClFN2 |
| Molarna masa | 226.677 g/mol |
| |
Vidi još
уредиReference
уреди- ^ Quarta D, Naylor CG, Stolerman IP. The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination. Psychopharmacology (Berlin). 2007 Aug;193(3):391-402. PMID 17473916
- ^ Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008 May;33(6):1402-12. PMID 17653111
- ^ Porter, R H P.; Benwell, K. R.; Lamb, H.; Malcolm, C. S.; Allen, N. H.; Revell, D. F.; Adams, D. R.; Sheardown, M. J. (1999). „Functional characterization of agonists at recombinant human 5-HT2A , 5-HT2B and 5-HT2C receptors in CHO-K1 cells”. British Journal of Pharmacology. 128 (1): 13—20. PMC 1571597
. PMID 10498829. doi:10.1038/sj.bjp.0702751.
- ^ Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, Kindel GH, Haskins KA, Shankaran M, Petersen BR, Van De Kar LD. Neuroendocrine evidence that (S)-2-(6-chloro-5-fluoro-indol-1-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist. Journal of Pharmacology and Experimental Therapeutics. 2003 Mar;304(3):1209-16. PMID 12604698
Spoljašnje veze
уреди
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