CCL5

Hemokin (C-C motiv) ligand 5
Hemokin (C-C motiv) ligand 5
	PDB prikaz baziran na 1pmi.
Dostupne strukture
	1b3a, 1eqt, 1hrj, 1rtn, 1rto, 1u4l, 1u4m, 1u4p, 1u4r
Identifikatori
Simboli	CCL5; D17S136E; MGC17164; RANTES; SCYA5; SISd; TCP228
Vanjski ID	OMIM: 187011 MGI: 98262 HomoloGene: 2244 GeneCards: CCL5 Gene
Ontologija gena
Molekularna funkcija	• transdukcija signala; • hemokinska aktivnost; • hemoatraktantska aktivnost;
Celularna komponenta	• ekstracelularni region; • inflamatorni odgovor;
Biološki proces	• ćelijska homeostaza kalcijum jona; • egzocitoza; • ćelijska pokretljivost; • hemotaksa; • inflamatorni odgovor; • imunski odgovor; • ćelijski odbrambeni odgovor; • respons na oksidativni stres; • ćelijska adhezija; • transdukcija signala; • interćelijska signalizacija; • respons na viruse;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	6352
Ensembl	ENSG00000161570
UniProt	P13501
RefSeq (mRNA)	NM_002985
RefSeq (protein)	NP_002976
Lokacija (UCSC)	Chr 17:; 31.22 - 31.23 Mb
PubMed pretraga	[1]

CCL5, hemokin (C-C motiv) ligand 5, takođe poznat kao RANTES (engl. Regulated upon Activation, Normal T-cell Expressed, and Secreted) je protein koji je kod ljudi kodiran CCL5 genom.^[1]^[2]

Funkcija

CCL5 je 8 kDa protein koji je klasifikovan kao hemotaksni citokin ili hemokin. CCL5 je hemoatraktant T ćelija, eozinofila, i bazofila. On učestvuje u regrutovanju leukocita na mesta zapaljenja. Uz pomoć određenih citokina (npr., IL-2 i IFN-γ) koji se oslobađaju iz T ćelija, CCL5 takođe stimuliše proliferaciju i aktivaciju pojedinih tipova (NK) ćelija da formiraju CHAK (CC-hemokin-aktivirane ubice) ćelije.^[3] CCL5 je takođe HIV-supresivni faktor koji izlučuju CD8+ T ćelije. Gen ovog hemokina je lociran na hromozomu 17 kod ljudi.^[4]

RANTES je prvobitno bio identifikovan u toku potrage za "kasno" izraženim genima (3–5 dana) nakon T ćelijske aktivacije. Naknadno je bilo utvrđeno da je on CC hemokin i da je izražen u više od 100 ljudskih bolesti. RANTES izražavanje je regulisano u T limfocitima Krupel sličnim faktorom 13 (KLF13).^[5]^[6]^[7]^[8]

Interakcije

Za CCL5 se zna da formira interakcije sa CCR3,^[9]^[10] CCR5^[10]^[11]^[12] and CCR1.^[10]^[12]

CCL5 takođe aktivira G-protein spregnuti receptor GPR75.^[13]

Vidi još

Reference

^ Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (1990). „Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12”. Genomics. 6 (3): 548—53. PMID 1691736. doi:10.1016/0888-7543(90)90485-D.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Maghazachi; et al. (1996). „CC chemokines induce the generation of killer cells from CD56+ cells”. Eur J Immunol. 26: 315—9. PMID 8617297.
^ Donlon; et al. (1990). „Localization of a human T-cell-specific gene, CCL5 (D17S136E), to chromosome 17q11.2-q12.”. Genomics. 5: 548—553. PMID 1691736.
^ Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM (1988). „A human T cell-specific molecule is a member of a new gene family”. J. Immunol. 141 (3): 1018—25. PMID 2456327.
^ Krensky, Alan M. (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co. ISBN 978-1-57059-253-9.
^ Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (1999). „RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes”. Immunity. 10 (1): 93—103. PMID 10023774. doi:10.1016/S1074-7613(00)80010-2.
^ Song A, Nikolcheva T, Krensky AM (2000). „Transcriptional regulation of RANTES expression in T lymphocytes”. Immunol. Rev. 177: 236—45. PMID 11138780. doi:10.1034/j.1600-065X.2000.17610.x.
^ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (1996). „Cloning, expression, and characterization of the human eosinophil eotaxin receptor”. J. Exp. Med. 183 (5): 2349—54. PMC 2192548  . PMID 8642344.
^ ^а ^б ^в Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (2001). „Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils”. Eur. J. Immunol. 31 (7): 2170—8. PMID 11449371. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D.
^ Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L (2003). „Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages”. Biochim. Biophys. Acta. 1617 (1-2): 80—8. PMID 14637022.
^ ^а ^б Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (2001). „The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity”. J. Biol. Chem. 276 (14): 10620—6. PMID 11116158. doi:10.1074/jbc.M010867200.
^ Ignatov A, Robert J, Gregory-Evans C, Schaller HC (2006). „RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with [[G protein spregnuti receptori|G protein-coupled receptor]] 75”. Br. J. Pharmacol. 149 (5): 490—7. PMC 2014681  . PMID 17001303. doi:10.1038/sj.bjp.0706909. Сукоб URL—викивеза (помоћ)

Literatura

Muthumani K; Desai BM; Hwang DS; et al. (2004). „HIV-1 Vpr and anti-inflammatory activity.”. DNA Cell Biol. 23 (4): 239—47. PMID 15142381. doi:10.1089/104454904773819824.
Zhao RY, Elder RT (2005). „Viral infections and cell cycle G2/M regulation.”. Cell Res. 15 (3): 143—9. PMID 15780175. doi:10.1038/sj.cr.7290279.
Zhao RY, Bukrinsky M, Elder RT (2005). „HIV-1 viral protein R (Vpr) & host cellular responses.”. Indian J. Med. Res. 121 (4): 270—86. PMID 15817944.
Li L; Li HS; Pauza CD; et al. (2006). „Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.”. Cell Res. 15 (11-12): 923—34. PMID 16354571. doi:10.1038/sj.cr.7290370.
Krensky, Alan M. (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co.

Spoljašnje veze

CCL5 GeneCard

[pmid1691736-1] Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (1990). „Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12”. Genomics. 6 (3): 548—53. PMID 1691736. doi:10.1016/0888-7543(90)90485-D.

[2] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[3] Maghazachi; et al. (1996). „CC chemokines induce the generation of killer cells from CD56+ cells”. Eur J Immunol. 26: 315—9. PMID 8617297.

[4] Donlon; et al. (1990). „Localization of a human T-cell-specific gene, CCL5 (D17S136E), to chromosome 17q11.2-q12.”. Genomics. 5: 548—553. PMID 1691736.

[pmid2456327-5] Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM (1988). „A human T cell-specific molecule is a member of a new gene family”. J. Immunol. 141 (3): 1018—25. PMID 2456327.

[isbn1-57059-253-5-6] Krensky, Alan M. (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co. ISBN 978-1-57059-253-9.

[pmid10023774-7] Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (1999). „RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes”. Immunity. 10 (1): 93—103. PMID 10023774. doi:10.1016/S1074-7613(00)80010-2.

[pmid11138780-8] Song A, Nikolcheva T, Krensky AM (2000). „Transcriptional regulation of RANTES expression in T lymphocytes”. Immunol. Rev. 177: 236—45. PMID 11138780. doi:10.1034/j.1600-065X.2000.17610.x.

[pmid8642344-9] Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (1996). „Cloning, expression, and characterization of the human eosinophil eotaxin receptor”. J. Exp. Med. 183 (5): 2349—54. PMC 2192548  . PMID 8642344.

[pmid11449371-10] а ^б ^в Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (2001). „Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils”. Eur. J. Immunol. 31 (7): 2170—8. PMID 11449371. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D.

[pmid14637022-11] Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L (2003). „Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages”. Biochim. Biophys. Acta. 1617 (1-2): 80—8. PMID 14637022.

[pmid11116158-12] а ^б Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (2001). „The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity”. J. Biol. Chem. 276 (14): 10620—6. PMID 11116158. doi:10.1074/jbc.M010867200.

[pmid17001303-13] Ignatov A, Robert J, Gregory-Evans C, Schaller HC (2006). „RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with [[G protein spregnuti receptori|G protein-coupled receptor]] 75”. Br. J. Pharmacol. 149 (5): 490—7. PMC 2014681  . PMID 17001303. doi:10.1038/sj.bjp.0706909. Сукоб URL—викивеза (помоћ)

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