Psilocibin

Psilocibin
IUPAC ime
	[3-(2-dimetilaminoetil)-1H-indol-4-il] dihidrogen fosfat
Pravni status
Pravni status	AU: S9 (Zabranjen) ; CA: Schedule III ; UK: Klasa A ; US: Schedule I ;
Identifikatori
CAS broj	520-52-5
ATC kod	none
PubChem	CID 10624
ChemSpider	10178
KEGG	C07576
ChEMBL	CHEMBL194378
Hemijski podaci
Formula	C12H17N2O4P
Molarna masa	284,25 g/mol
	SMILES O=P(O)(O)Oc1cccc2c1c(cn2)CCN(C)C; ;
	InChI InChI=1S/C12H17N2O4P/c1-14(2)7-6-9-8-13-10-4-3-5-11(12(9)10)18-19(15,16)17/h3-5,8,13H,6-7H2,1-2H3,(H2,15,16,17) ; Key:QVDSEJDULKLHCG-UHFFFAOYSA-N ;

Psilocibin (ili 4-PO-DMT) je halucinogeni sastojak prisutan u velikom broju gljiva iz roda Psilocybe, koje se u žarogonu zovu magične gljive.^[1] U nekim plemenskim kulturama gljive se uživaju u religiozno-mistične svrhe. Danas je uživanje psilociba, iako u nekim zemljama nezakonito, sve više rasprostranjeno u zapadnom svetu.

Psilocibin je izuzetno aktivna materija.^[2]^[3] Efekti psilocibina se porede sa efektima LSD-a, samo kraćeg trajanja. Prvi efekti se javljaju već pri dozi od 0,5 grama osušenih gljiva. Simptomi nastaju 30min - 1 časa nakon konzumacije, a sastoje se od iznenadne zbunjenosti, mišićne slabosti, usporenja pulsa i sniženja krvnog pritiska i psihoznih efekata koji mogu biti ugodni, ali i neugodni. Pojavljuju se halucinacija i poremećaj percepcije vremena i prostora a nekad i euforija ili depresija. Efekti obično traju 4 do 6 časova.

Reference

^ Beck O, Helander A, Karlson-Stiber C, Stephansson N (1998). „Presence of phenylethylamine in hallucinogenic Psilocybe mushroom: possible role in adverse reactions”. Journal of Analytical Toxicology. 22 (1): 45—9. PMID 9491968.
^ Abramson HA, Rolo A (1965). „Lysergic acid diethylamide (LSD-25). 38. Comparison with action of methysergide and psilocybin on test subjects”. The Journal of Asthma Research. 3 (1): 81—96. PMID 5318626. doi:10.3109/02770906509106904.
^ Adams JD Jr. (2009). „Chemical Interactions with pyramidal neurons in layer 5 of the cerebral cortex: control of pain and anxiety”. Current Medicinal Chemistry. 16 (27): 3476—9. PMID 19799545. doi:10.2174/092986709789057626.

Literatura

Boire RG. (2002). Sacred Mushrooms and the Law. Berkeley, California: Ronin Publishing. ISBN 978-1579510619.
Doblin R. (1991). „Pahnke's "Good Friday Experiment": A long-term follow-up and methodological critique” (PDF). Journal of Transpersonal Psychology. 23 (1): 1—25. Архивирано из оригинала (PDF) 16. 08. 2012. г. Приступљено 14. 07. 2011.
Marley G. (2010). „Chapter 13. Psilocybin: Gateway to the Soul or Just a Good High?”. Chanterelle Dreams, Amanita Nightmares: The Love, Lore, and Mystique of Mushrooms. White River Junction, Vermont: Chelsea Green Publishing. стр. 163-84. ISBN 978-1-60358-214-8.
Ott J. (1993). Pharmacotheon Entheogenic Drugs Their Plant Sources and Histories. Kennewick, Washington: Natural Products Company. ISBN 978-0961423438.
Stafford PJ. (1992). Psychedelics Encyclopedia. Berkeley, California: Ronin Publishing. ISBN 978-0-914171-51-5.
Stamets P. (1996). Psilocybin Mushrooms of the World: An Identification Guide. Berkeley, California: Ten Speed Press. ISBN 978-0-89815-839-7.

2006 Džon Hopkinsovi eksperimenti

"Hopkins Scientists Show Hallucinogen in Mushrooms Creates Universal 'Mystical' Experience", Johns Hopkins Medicine news release, July 11, 2006.
"Q&A is with Roland Griffiths, the study’s lead researcher", Johns Hopkins Medicine news release, July 11, 2006.
"Psilocybin Viewed as Therapy or Research Tool" by Michael Smith, Medpagetoday.com, July 12, 2006.
"Magic mushrooms really cause 'spiritual' experiences" by Roxanne Khamsi, New Scientist news service, July 11, 2006.
"Drug's Mystical Properties Confirmed" by David Brown, Washington Post, July 11, 2006.
"Mushroom Drug Produces Mystical Experience", Associated Press, July 11, 2006.
"Counterculture Drug Provides Spiritual Boost" by Denise Gellene, Los Angeles Times, July 11, 2006.
"Tripping Out: Scientists Study Mystical Effects of Mushrooms" by Joy Victory, Bharathi Radhakrishnan, and Andrea Carter, ABC News (online), July 11, 2006. ABC News video report of the study.

2008 Nastavak Džon Hopkinsovih eksperimenta

"A Very Memorable Trip", by Greg Miller, ScienceNOW Daily News, July 1, 2008
"Spiritual Effects of Hallucinogens Persist, Johns Hopkins Researchers Report", Johns Hopkins Medicine news release, July 1, 2008.
"Psilocybin Study Hints at Rebirth of Hallucinogen Research", by Brandon Keim, "Wired," July 1, 2008
"Sacred Intentions: Inside the Johns Hopkins Psilocybin Studies" by Michael M. Hughes, Baltimore City Paper, October 8, 2008.

Spoljašnje veze

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[Beck1998-1] Beck O, Helander A, Karlson-Stiber C, Stephansson N (1998). „Presence of phenylethylamine in hallucinogenic Psilocybe mushroom: possible role in adverse reactions”. Journal of Analytical Toxicology. 22 (1): 45—9. PMID 9491968.

[Abramson1965-2] Abramson HA, Rolo A (1965). „Lysergic acid diethylamide (LSD-25). 38. Comparison with action of methysergide and psilocybin on test subjects”. The Journal of Asthma Research. 3 (1): 81—96. PMID 5318626. doi:10.3109/02770906509106904.

[Adams2009-3] Adams JD Jr. (2009). „Chemical Interactions with pyramidal neurons in layer 5 of the cerebral cortex: control of pain and anxiety”. Current Medicinal Chemistry. 16 (27): 3476—9. PMID 19799545. doi:10.2174/092986709789057626.

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