T-Plasminogeni aktivator
(преусмерено са Plazminogenski aktivator, tkivni-tip)
T-Plasminogeni aktivator (EC 3.4.21.68, tkivni plazminogenski activator, plazminogenski aktivator, tkivni-tip, tkivni tip plazminogenskog aktivatora, tPA, t-PA) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| T-Plasminogeni aktivator | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.21.68 | ||||||||
| CAS broj | 139639-23-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Specifično razlaganje Arg-Val veze u plazminogenu čime se formira plazmin
Ova peptidaza je prisutna u širokom opsegu tipova tkiva, a posebno u endotelnim ćelijama.
Reference
уреди- ^ Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D. (1983). „Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli”. Nature. 301: 214—221. PMID 6337343.
- ^ Loskutoff, D.J. & Schleef, R.R. (1988). „Plasminogen activators and their inhibitors”. Methods Enzymol. 163: 293—302. PMID 3148826.
- ^ Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E. (1988). „The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage”. Biochim. Biophys. Acta. 952: 245—254. PMID 2962643.
- ^ Verheijen, J.H. (1988). „Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma”. Methods Enzymol. 163: 302—309. PMID 3148827.
- ^ Gerard, R.D. & Meidell, R.S. (1989). „Regulation of tissue plasminogen activator expression”. Annu. Rev. Physiol. 51: 245—262. PMID 2496643.
- ^ Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. Ур.: Handin, R.I., Lux, S.E. and Stossel, J.P. Blood: Principles and Practice of Hematology (2nd изд.). Philadelphia: J.B.Lippincott Company. стр. —.
Литература
уреди- Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. Ур.: Handin, R.I., Lux, S.E. and Stossel, J.P. Blood: Principles and Practice of Hematology (2nd изд.). Philadelphia: J.B.Lippincott Company. стр. —.
Spoljašnje veze
уреди- T-plasminogen+activator на US National Library of Medicine Medical Subject Headings (MeSH)
