Peptidaza-55 razlaganja međuproizvoda
Peptidaza-55 razlaganja međuproizvoda (EC 3.4.11.26, Icp55, peptidaza 55 kDa razlaganja mitohondrijskih intermedijera) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Peptidaza-55 razlaganja međuproizvoda | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.26 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Ovaj enzim ralaže Pro36-Pro37 vezu cisteinske desumporaze (EC 2.8.1.7) čime se uklanjaju tri aminokiselinska ostatka (Tyr-Ser-Pro) sa N-terminusa nakon razlaganja mitohondrijskom peptidazom
Icp55 uklanja destabilizujuće N-terminalne aminokiselinske ostatke zaostale nakon razlaganja posredstvom mitohondrijske peptidaze.
Reference
уреди- ^ Naamati, A., Regev-Rudzki, N., Galperin, S., Lill, R. and Pines, O. (2009). „Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55”. J. Biol. Chem. 284: 30200—30208. PMID 19720832.
- ^ Vogtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N. and Meisinger, C. (2009). „Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability”. Cell. 139: 428—439. PMID 19837041.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Intermediate+cleaving+peptidase+55 на US National Library of Medicine Medical Subject Headings (MeSH)
