Natrijum tiopental

Natrijum tiopental
IUPAC ime
	5-etil-5-(pentan-2-il)-2-fulfaniliden-1,3-diazinan-4,6-dion
Klinički podaci
Prodajno ime	Farmotal, Intraval, Nesdonal, Thiothal
Drugs.com	thiopental.html Monografija
Način primene	Intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	3-8 sati
Identifikatori
CAS broj	76-75-5
ATC kod	N01AF03 (WHO), N05CA19
PubChem	CID 3000715
IUPHAR/BPS	2579
DrugBank	DB00599
ChemSpider	2272258
KEGG	C07521
ChEMBL	CHEMBL102166
Hemijski podaci
Formula	C11H18N2O2S
Molarna masa	242.338
	SMILES CCCC(C)C1(CC)C(=O)NC(=S)NC1=O; ;
	InChI InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16) ; Key:IUJDSEJGGMCXSG-UHFFFAOYSA-N ;

Natrijum tiopental je barbiturat koji se intravenozno administrira radi indukcije opšte anestezije ili ostvarivanja kompletne anestezije tokom kratkog vremenskog perioda. On se takođe korisiti pri hipnozi, i kontroli konvulzivnih stanja. On je primenjivan kod neurohirurških pacijenata s ciljem snižavanja povišenog intrakranijalnog pritiska. On ne proizvodi pobuđenost ali ima slaba analgetička i mišićno relaksantna svojstva.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Reference

^ Martindale, The Extra Pharmacopoeia, 30th ed, p920
^ Morgan DJ, Blackman GL, Paull JD, Wolf LJ: Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology. 1981 Jun;54(6):474-80. PMID 7235275
^ Perez-Barcena J, Barcelo B, Homar J, Abadal JM, Molina FJ, de la Pena A, Sahuquillo J, Ibanez J: [Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients] Neurocirugia (Astur). 2005 Feb;16(1):5-12; discussion 12-3. PMID 15756405
^ WINTERS WD, SPECTOR E, WALLACH DP, SHIDEMAN FE: Metabolism of thiopental-S35 and thiopental-2-C14 by a rat liver mince and identification of pentobarbital as a major metabolite. J Pharmacol Exp Ther. 1955 Jul;114(3):343-57. PMID 13243246
^ Bory C, Chantin C, Boulieu R, Cotte J, Berthier JC, Fraisse D, Bobenrieth MJ: [Use of thiopental in man. Determination of this drug and its metabolites in plasma and urine by liquid phase chromatography and mass spectrometry] C R Acad Sci III. 1986;303(1):7-12. PMID 3093002
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

Spoljašnje veze

Sodium thiopental

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Martindale, The Extra Pharmacopoeia, 30th ed, p920

[2] Morgan DJ, Blackman GL, Paull JD, Wolf LJ: Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology. 1981 Jun;54(6):474-80. PMID 7235275

[3] Perez-Barcena J, Barcelo B, Homar J, Abadal JM, Molina FJ, de la Pena A, Sahuquillo J, Ibanez J: [Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients] Neurocirugia (Astur). 2005 Feb;16(1):5-12; discussion 12-3. PMID 15756405

[4] WINTERS WD, SPECTOR E, WALLACH DP, SHIDEMAN FE: Metabolism of thiopental-S35 and thiopental-2-C14 by a rat liver mince and identification of pentobarbital as a major metabolite. J Pharmacol Exp Ther. 1955 Jul;114(3):343-57. PMID 13243246

[5] Bory C, Chantin C, Boulieu R, Cotte J, Berthier JC, Fraisse D, Bobenrieth MJ: [Use of thiopental in man. Determination of this drug and its metabolites in plasma and urine by liquid phase chromatography and mass spectrometry] C R Acad Sci III. 1986;303(1):7-12. PMID 3093002

[6] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[7] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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