NADPH—hemoprotein reduktaza
NADPH—hemoprotein reduktaza (EC 1.6.2.4, CPR, FAD-citohrom c reduktaza, NADP---citohrom c reduktaza, NADP---citohrom reduktaza, NADPH-zavisna citohrom c reduktaza, NADPH:P-450 reduktaza, NADPH:ferihemoproteinska oksidoreduktaza, NADPH---citohrom P-450 oksidoreduktaza, NADPH---citohrom c oksidoreduktaza, NADPH---citohrom c reduktaza, NADPH---citohrom p-450 reduktaza, NADPH---fericitohrom c oksidoreduktaza, NADPH---ferihemoproteinska reduktaza, TPNH2 citohrom c reduktaza, TPNH-citohrom c reduktaza, aldehidna reduktaza (NADPH-zavisna), citohrom P-450 reduktaza, citohrom c reduktaza, dihidroksinikotinamid adenin dinukleotid fosfat-citohrom c reduktaza, ferihemoprotein P-450 reduktaza, redukovani nikotinamid adenin dinukleotid fosfat-citohrom c reduktaza, reduktaza, citohrom c (redukovani nikotinamid adenin dinukleotid fosfat)) je enzim sa sistematskim imenom NADPH:hemoprotein oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
| NADPH—hemoprotein reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 NADPH—hemoprotein reduktaza dimer, Rattus norvegicus | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.6.2.4 | ||||||||
| CAS broj | 2601686 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- NADPH + H+ + n oksidovani hemoprotein NADP+ + n redukovani hemoprotein
Ovaj enzim je flavoprotein (FMN, FAD) koji sadrži FMN i FAD. Broj n u jednačini je 1 ako hemoprotein podleže dvoelektronskoj redukciji, a njegova vrednost je 2 pri jednoelektronskoj redukciji.
Reference
уреди- ^ Haas, E., Horecker, B.L. and Hogness, T.R. (1940). „The enzymatic reduction of cytochrome c, cytochrome c reductase”. J. Biol. Chem. 136: 747—774.
- ^ Horecker, B.L. (1950). „Triphosphopyridine nucleotide-cytochrome c reductase in liver”. J. Biol. Chem. 183: 593—605.
- ^ Lu, A.Y.H., Junk, K.W. and Coon, M.J. (1969). „Resolution of the cytochrome P-450-containing ω-hydroxylation system of liver microsomes into three components”. J. Biol. Chem. 244: 3714—3721. PMID 4389465.
- ^ Masters, B.S.S., Kamin, H., Gibson, Q.H. and Williams, C.H., Jr. (1965). „Studies on the mechanism of microsomal triphosphopyridine nucleotide-cytochrome c reductase”. J. Biol. Chem. 240: 921—931. PMID 14275154.
- ^ Williams, C.H., Jr. & Kamin, H. (1962). „Microsomal triphosphopyridine nucleotide-cytochrome c reductase in liver”. J. Biol. Chem. 237: 587—595. PMID 14007123.
- ^ Masters, B.S.S., Bilimoria, M.H, Kamen, H. and Gibson, Q.H. (1965). „The mechanism of 1- and 2-electron transfers catalyzed by reduced triphosphopyridine nucleotide-cytochrome c reductase”. J. Biol. Chem. 240: 4081—4088. PMID 4378860.
- ^ Sevrioukova, I.F. & Peterson, J.A. (1995). „NADPH-P-450 reductase: Structural and functional comparisons of the eukaryotic and prokaryotic isoforms”. Biochimie. 77: 562—572. PMID 8589067.
- ^ Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S.S. and Kim, J.-J.P. (1997). „Three-dimensional structure of NADPH-cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes”. Proc. Natl. Acad. Sci. USA. 94: 8411—8416. PMID 9237990.
- ^ Munro, A.W., Noble, M.A., Robledo, L., Daff, S.N. and Chapman, S.K. (2001). „Determination of the redox properties of human NADPH-cytochrome P450 reductase”. Biochemistry. 40: 1956—1963. PMID 11329262.
- ^ Gutierrez, A., Grunau, A., Paine, M., Munro, A.W., Wolf, C.R., Roberts, G.C.K. and Scrutton, N.S. (2003). „Electron transfer in human cytochrome P450 reductase”. Biochem. Soc. Trans. 31: 497—501. PMID 12773143.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- NADPH---hemoprotein+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
