Ksilamidin
Ksilamidin je lek koji deluje kao antagonist 5HT2A receptora, i u manjoj meri 5HT1A receptora. On ne prelazi krvno moždanu barijeru iz kog razloga je koristan za blokiranje perifernih serotonergijskih responsa poput kardiovaskularnog[1][2] i gastrointestinalnog dejstva,[3] bez proizvođenja centralnih efekata 5HT2A blokade kao što je sedacija, ili ometanja centralno delujućih 5HT2A agonista.[4]
IUPAC ime | |
---|---|
N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide | |
Identifikatori | |
CAS broj | 6443-50-1 |
ATC kod | none |
PubChem | CID 22951 |
Hemijski podaci | |
Formula | C19H24N2O2 |
Molarna masa | 312.406 g/mol |
|
Literatura
уреди- ^ Fuller, RW; Kurz, KD; Mason, NR; Cohen, ML (1986). „Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67”. European journal of pharmacology. 125 (1): 71—7. PMID 3732393.
- ^ Dedeoğlu, A; Fisher, LA (1991). „Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms”. The Journal of pharmacology and experimental therapeutics. 259 (3): 1027—34. PMID 1762059.
- ^ Baker, BJ; Duggan, JP; Barber, DJ; Booth, DA (1988). „Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats”. European journal of pharmacology. 150 (1-2): 137—42. PMID 3402534.
- ^ Dave, KD; Quinn, JL; Harvey, JA; Aloyo, VJ (2004). „Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit”. Pharmacology, biochemistry, and behavior. 77 (3): 623—9. PMID 15006475. doi:10.1016/j.pbb.2003.12.017.
Spoljašnje veze
уреди
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