Kortikotropinu-sličan intermedijarni peptid
Kortikotropin-sličan intermedijarni peptid[3] (CLIP, adrenokortikotropni hormonski fragment 18-39, ACTH (18-39)) je prirodni endogeni neuropeptid sa dokozapeptidnom strukturom i aminokiselinskom sekvencom Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP nastaje kao proizvod proteolitičkog razlaganja adrenokortikotropnog hormona (ACTH),[4][5] koji je produkt razlaganja proopiomelanokortina (POMC).[6] Mada ne izgleda da ima posebno važnu ulogu u telu,[7] on ima izvesna biološka dejstva,[8][9] posebno u neurološkim sistemima.[10][11][12][13][14]
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| Nazivi | |
|---|---|
| IUPAC naziv
L-arginil-L-prolil-L-valil-L-lizil-L-valil-L-tirozil-L-prolil-L-asparaginil-L-glicil-L-alanil-L-α-glutamil-L-α-aspartil-L-α-glutamil-L-seril-L-alanil-L-α-glutamil-L-alanil-L-fenilalanil-L-prolil-L-leucil-L-α-glutamil-L-fenilalanin
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| Identifikacija | |
| ChemSpider | |
| Svojstva | |
| C112H165N27O36 | |
| Molarna masa | 2465,668 g/mol |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
| Reference infokutije | |
Vidi još
уреди- Adrenokortikotropni hormon (ACTH)
- Proopiomelanokortin (POMC)
Reference
уреди- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Silvana Andrić; Tatjana Kostić; Nebojša Andrić; Sonja Zorić (2006). Uporedna fiziologija životinja (PDF). Novi Sad: WUS Austria, Daniel Print. ISBN 86-7031-074-0.
- ^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (1979). „Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia”. The Journal of Biological Chemistry. 254 (23): 11903—6. PMID 227883. Архивирано из оригинала 15. 09. 2019. г. Приступљено 26. 12. 2012.
- ^ Fricker, Lloyd D. (24. 7. 1991). Peptide biosynthesis and processing. CRC Press. стр. 78. ISBN 978-0-8493-8852-1. Приступљено 25. 11. 2011.
- ^ Norman, Anthony W.; Litwack, Gerald (26. 9. 1997). Hormones. Academic Press. стр. 12. ISBN 978-0-12-521441-4. Приступљено 25. 11. 2011.
- ^ Larry Rex Engelking (1. 6. 2002). Review of veterinary physiology. Teton NewMedia. стр. 411. ISBN 978-1-893441-69-9. Приступљено 25. 11. 2011.
- ^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (1984). „Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules”. The Journal of Clinical Investigation. 74 (5): 1886—9. PMC 425369
. PMID 6209301. doi:10.1172/JCI111608.
- ^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (1991). „Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain”. Brain Research Bulletin. 26 (1): 99—111. PMID 1849784.
- ^ Inoué, Shojiro; Inoué, Shojiro (1989). Biology of sleep substances. CRC Press. стр. 136. ISBN 978-0-8493-4822-8. Приступљено 25. 11. 2011.
- ^ Chastrette N, Cespuglio R, Jouvet M (1990). „Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives”. Neuropeptides. 15 (2): 61—74. PMID 1981927.
- ^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (1990). „Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes”. Neuropeptides. 15 (2): 75—88. PMID 1964203.
- ^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (2009). „Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain”. Bulletin of Experimental Biology and Medicine. 147 (3): 319—22. PMID 19529852.
- ^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). „Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]”. Peptides. 14 (6): 1221—4. PMID 8134304.
Literatura
уреди- Inoué, Shojiro; Inoué, Shojiro (1989). Biology of sleep substances. CRC Press. стр. 136. ISBN 978-0-8493-4822-8. Приступљено 25. 11. 2011.
- Larry Rex Engelking (2002). Review of veterinary physiology. Teton NewMedia. стр. 411. ISBN 978-1-893441-69-9. Приступљено 25. 11. 2011.
- Norman, Anthony W.; Litwack, Gerald (1997). Hormones. Academic Press. стр. 12. ISBN 978-0-12-521441-4. Приступљено 25. 11. 2011.
- Fricker, Lloyd D. (1991). Peptide biosynthesis and processing. CRC Press. стр. 78. ISBN 978-0-8493-8852-1. Приступљено 25. 11. 2011.
Spoljašnje veze
уреди
- Corticotropin-Like+Intermediate+Lobe+Peptide на US National Library of Medicine Medical Subject Headings (MeSH)