Komplementni faktor I
Komplementni faktor I (EC 3.4.21.45, komplementno komponentni C3b inaktivator, C3b inaktivator, C3b/C4b inaktivator, C3bINA, komplementni C3b/C4b inaktivator, komplementni C4b inaktivator, konglutinogen-aktivirajući faktor C, komplementni C3b inaktivator, faktor I, komplement C4bi) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Komplementni faktor I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.45 | ||||||||
| CAS broj | 80295-66-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Inaktivatcija proteolitičkim razlaganjem komplementnih potkomponenti C3b, iC3b i C4b
Za odvajanje komplementne potkomponente C3b je neophodno njeno vezivanje za kofaktor faktor H ili komplementni receptor CR1.
Reference
уреди- ^ Nagasawa, S., Ichihara, C. and Stroud, R.M. (1980). „Cleavage of C4b by C3b inactivator: production of a nicked form from C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator”. J. Immunol. 125: 578—582. PMID 7391570.
- ^ Crossley, L.G. (1981). „C3b inactivator and β1H”. Methods Enzymol. 80: 112—124. PMID 6210825.
- ^ Müller-Eberhard, H.J. (1988). „Molecular organization and function of the complement system”. Annu. Rev. Biochem. 57: 321—347. PMID 3052276.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Complement+factor+I на US National Library of Medicine Medical Subject Headings (MeSH)
