Katepsin V
Katepsin V (EC 3.4.22.43, katepsin L2, katepsin U) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Katepsin V | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.43 | ||||||||
| CAS broj | 223670-00-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Ovaj rekombinantni enzim hidrolizuje proteine (serumski albumin, kolagen) i sintetičke supstrate (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)
Katepsin V je ljudska lizozomalna cisteinska endopeptidaza iz familije C1 (papainske familije) koja je maksimalno aktivna na pH 5m7 i nestabilna na neutralnom pH.
Reference
уреди- ^ Brömme, D., Li, Z., Barnes, M. and Mehler, E. (1999). „Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization”. Biochemistry. 38: 2377—2385. PMID 10029531.
- ^ Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K. and Okubo, K. (1998). „Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium”. Invest. Ophthalmol. Vis. Sci. 39: 1789—1796. PMID 9727401.
- ^ Santamaría, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E. and López-Otín, C. (1998). „Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas”. Cancer Res. 58: 1624—1630. PMID 9563472.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Cathepsin+V на US National Library of Medicine Medical Subject Headings (MeSH)
