Kaspaza-1
Kaspaza-1 (EC 3.4.22.36, interleukin 1beta-konvertujući enzim, proteaza VII, proteaza A, interleukin 1beta prekurzorna proteinaza, interleukin 1 konvertujući enzim, interleukin 1beta-konvertujuća endopeptidaza, interleukin-1beta konvertaza, interleukin-1beta konvertujući enzim, interleukin-1beta prekurzorna proteinaza, prointerleukin 1beta proteaza, prekurzor interleukin-1beta konvertujući enzim, pro-interleukinska 1beta proteinaza, ICE) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kaspaza-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.22.36 | ||||||||
| CAS broj | 122191-40-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Hidroliza proteina, pri čemu je neophodno da je Asp ostatak u pozicija P1. Preferentne sekvenca razlaganja je Tyr-Val-Ala-Asp-
Ovaj enzim se javlja u monocitima sisara.
Reference
уреди- ^ Howard, A., Kostura, M.J., Thornberry, N., Ding, G.J.., Limjuco, G., Weidner, J., Salley, J.P., Hogquist, K.A., Chaplin, D.D., Mumford, R.A., Schmidt, J.A. and Tocci, M.J. (1991). „IL-1 converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDa IL-1α”. J. Immunol. 147: 2964—2969. PMID 1919001.
- ^ Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J., Elliston, K.O., Ayala, J.M., Casano, F (1992). „J., Chin, J., Ding, G.J.-F., Egger, L.A., Gaffney, E.P., Limjuco, G., Palyha, O.C., Raju, S.M., Rolando, A.M., Salley, J.P., Yamin, T.-T. and Tocci, M.J. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes”. Nature. 356: 768—774. PMID 1574116.
- ^ Thornberry, N.A. (1994). „Interleukin-1β converting enzyme”. Methods Enzymol. 244: 615—631. PMID 7845238.
- ^ Alnemri, E.S., Livingston, D.J., Nicholson, D.W., Salvesen, G., Thornberry, N.A., Wong, W.W. and Yuan, J.Y. (1996). „Human ICE/CED-3 protease nomenclature”. Cell. 87: 171—171. PMID 8861900.
- ^ Margolin, N., Raybuck, S.A., Wilson, K.P., Chen, W.Y., Fox, T., Gu, Y. and Livingston, D.J. (1997). „Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases”. J. Biol. Chem. 272: 7223—7228. PMID 9054418.
- ^ Martinon, F. & Tschopp, J. (2004). „Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases”. Cell. 117: 561—574. PMID 15163405.
- ^ Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
