Ikosanoil-KoA sintaza
Ikosanoil-KoA sintaza (EC 2.3.1.119, acil-KoA elongaza, C18-KoA elongaza, stearoil-KoA elongaza) je enzim sa sistematskim imenom stearoil-KoA:malonil-KoA C-aciltransferaza (dekarboksilacija, oksoacil- i enoil-redukcija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ikosanoil-KoA sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.119 | ||||||||
| CAS broj | 141256-55-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- stearoil-KoA + malonil-KoA + 2 NAD(P)H + 2 H+ ikosanoil-KoA + CO2 + KoA + 2 NAD(P)+ + H2O
Ikosanoil-KoA može da deluje umesto stearoil-KoA. Ovaj membranski enzim produžava dugolančane masne-acil-KoA.
Reference
уреди- ^ Bessoule, J.-J., Lessire, R. and Cassagne, C. (1989). „Partial purification of the acyl-CoA elongase of Allium porrum leaves”. Arch. Biochem. Biophys. 268: 475—484. PMID 2913944.
- ^ Bessoule, J.-J., Lessire, R., Rigoulet, M., Guerin, B. and Cassagne, C. (1987). „Fatty acid synthesis in mitochondria from Saccharomyces cerevisiae”. FEBS Lett. 214: 158—162. PMID 3552725.
- ^ Lessire, R., Bessoule, J.-J. and Cassagne, C. (1985). „Solubilization of C18 CoA and C20 CoA elongases from Allium porrum L. epidermal-cell microsomes”. FEBS Lett. 187: 314—320.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Icosanoyl-CoA+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
