Glutamin-(asparagin-)aza
Glutamin-(asparagin-)aza (EC 3.5.1.38, glutaminaza-asparaginaza, ansB (gen), L-asparagin/L-glutamin amidohidrolaza, L-ASNaza/L-GLNaza) je enzim sa sistematskim imenom L-glutamin(L-asparagin) amidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glutamin-(asparagin-)aza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.38 | ||||||||
| CAS broj | 39335-03-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Enzim iz bakterije Achromobacter hidrolizuje L-asparagin sa 0.8 brzine hidrolize L-glutamina.
Reference
уреди- ^ Roberts, J., Holcenberg, J.S. and Dolowy, W.C. (1972). „Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity”. J. Biol. Chem. 247: 84—90. PMID 5017769.
- ^ Tanaka, S., Robinson, E.A., Appella, E., Miller, M., Ammon, H.L., Roberts, J., Weber, I.T. and Wlodawer, A. (1988). „Structures of amidohydrolases. Amino acid sequence of a glutaminase-asparaginase from Acinetobacter glutaminasificans and preliminary crystallographic data for an asparaginase from Erwinia chrysanthemi”. J. Biol. Chem. 263: 8583—8591. PMID 3379033.
- ^ Lubkowski, J., Wlodawer, A., Ammon, H.L., Copeland, T.D. and Swain, A.L. (1994). „Structural characterization of Pseudomonas 7A glutaminase-asparaginase”. Biochemistry. 33: 10257—10265. PMID 8068664.
- ^ Ortlund, E., Lacount, M.W., Lewinski, K. and Lebioda, L. (2000). „Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu”. Biochemistry. 39: 1199—1204. PMID 10684596.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Glutamin-(asparagin-)ase на US National Library of Medicine Medical Subject Headings (MeSH)
