GNAI3, Guanin nukleotid-vezujući protein G(i), alfa-3 podjedinica, je protein koji je kod ljudi kodiran GNAI3 genom.Didsbury JR, Snyderman R (1987). „Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families”. FEBS Lett. 219 (1): 259—63. PMID 3109953. doi:10.1016/0014-5793(87)81228-0. </ref>[1]

Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 3
PDB prikaz baziran na 1agr.
Dostupne strukture
1agr​, 1as0​, 1as2​, 1as3​, 1bh2​, 1bof​, 1cip​, 1gdd​, 1gfi​, 1gg2​, 1gia​, 1gil​, 1git​, 1gp2​, 1kjy​, 1svk​, 1svs​, 1y3a​, 2g83​, 2gtp​, 2hlb​, 2ihb​, 2ik8​, 2ode
Identifikatori
Simboli GNAI3; 87U6; FLJ26559
Vanjski ID OMIM139370 MGI95773 HomoloGene55975 GeneCards: GNAI3 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2773 14679
Ensembl ENSG00000065135 ENSMUSG00000000001
UniProt P08754 Q3TJH1
RefSeq (mRNA) NM_006496 NM_010306
RefSeq (protein) NP_006487 NP_034436
Lokacija (UCSC) Chr 1:
109.89 - 109.94 Mb
Chr 3:
108.24 - 108.27 Mb
PubMed pretraga [1] [2]


Interakcije

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Za GNAI3 je bilo pokazano da ostvaruje interakcije sa RGS14,[2] RIC8A,[3] RGS18,[4][5] S1PR1,[6] RGS12,[2] RGS16,[7][8] RGS19,[9][10][11] RGS10[12] i RGS5.[7][13]

Reference

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  1. ^ „Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3”. 
  2. ^ а б Kimple, R J; De Vries L; et al. (2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. United States. 276 (31): 29275—81. ISSN 0021-9258. PMID 11387333. doi:10.1074/jbc.M103208200. 
  3. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200. 
  4. ^ Yowe, D; Weich N; et al. (2001). „RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes”. Biochem. J. England. 359 (Pt 1): 109—18. ISSN 0264-6021. PMC 1222126 . PMID 11563974. doi:10.1042/0264-6021:3590109. 
  5. ^ Gagnon, Alison W; Murray David L; Leadley Robert J (2002). „Cloning and characterization of a novel regulator of G protein signalling in human platelets”. Cell. Signal. England. 14 (7): 595—606. ISSN 0898-6568. PMID 11955952. doi:10.1016/S0898-6568(02)00012-8. 
  6. ^ Lee, M J; Evans M; Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. UNITED STATES. 271 (19): 11272—9. ISSN 0021-9258. PMID 8626678. doi:10.1074/jbc.271.19.11272. 
  7. ^ а б Chen, C; Zheng B; et al. (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. UNITED STATES. 272 (13): 8679—85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679. 
  8. ^ Beadling, C; Druey K M; et al. (1999). „Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes”. J. Immunol. UNITED STATES. 162 (5): 2677—82. ISSN 0022-1767. PMID 10072511. 
  9. ^ De Vries, L; Elenko E; et al. (1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203—8. ISSN 0027-8424. PMC 26381 . PMID 8986788. doi:10.1073/pnas.93.26.15203. 
  10. ^ Woulfe, D S; Stadel J M (1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. J. Biol. Chem. UNITED STATES. 274 (25): 17718—24. ISSN 0021-9258. PMID 10364213. doi:10.1074/jbc.274.25.17718. 
  11. ^ De Vries, L; Mousli M; et al. (1995). „GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 92 (25): 11916—20. ISSN 0027-8424. PMC 40514 . PMID 8524874. doi:10.1073/pnas.92.25.11916. 
  12. ^ Hunt, T W; Fields T A; et al. (1996). „RGS10 is a selective activator of G alpha i GTPase activity”. Nature. ENGLAND. 383 (6596): 175—7. ISSN 0028-0836. PMID 8774883. doi:10.1038/383175a0. 
  13. ^ Zhou, J; Moroi K; et al. (2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. England. 68 (13): 1457—69. ISSN 0024-3205. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0. 

Literatura

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