Flurazepam

Flurazepam
IUPAC ime
	7-hloro-1-[2-(dietilamino)etil]-5-(2-fluorofenil)-1,3-dihidro-2H-1,4-benzodiazepin-2-on
Klinički podaci
Prodajno ime	Dalmane
Drugs.com	Monografija
MedlinePlus	a682051
Kategorija trudnoće	X;
Način primene	Oralno
Pravni status
Pravni status	US: Schedule IV ;
Farmakokinetički podaci
Bioraspoloživost	83%
Metabolizam	Hepatički
Poluvreme eliminacije	40–250 sata
Izlučivanje	Renalno
Identifikatori
CAS broj	17617-23-1
ATC kod	N05CD01 (WHO)
PubChem	CID 3393
DrugBank	DB00690
ChemSpider	3276
UNII	IHP475989U
KEGG	D00329
ChEMBL	CHEMBL968
Hemijski podaci
Formula	C21H23ClFN3O
Molarna masa	387,88 g/mol
	SMILES FC1=CC=CC=C1C2=NCC(N(CCN(CC)CC)C3=C2C=C(C=C3)Cl)=O; ;
	InChI InChI=1S/C21H23ClFN3O/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23/h5-10,13H,3-4,11-12,14H2,1-2H3 ; Key:SAADBVWGJQAEFS-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	795 °C (1.463 °F)

Flurazepam^[1] (u prodaji pod imenima Dalmane i Dalmadorm) je lek iz benzodiazepinske klase. On poseduje anksiolitičkia, antikonvulsivna, sedativna i miorelaksantna svojstva. Iz flurazepama se formira metabolit sa veoma dugim poluživotom (40–250 sati), koji se može zadržati u krvi do četiri dana.^[2] Flurazepam stoga nije podesan za primenu kao sredstvo za spavanje, jer uzrokuje sedaciju narednog dana, mada taj efekat može da olakša anksiozne poteškoće.^[3]^[4]^[5]^[6]^[7]^[8]^[9]

Reference

^ BE Patent 629005
^ „Benzodiazepine Equivalence ”. Архивирано из оригинала 17. 07. 2007. г. Приступљено 07. 12. 2013.
^ Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. PMID 2883820
^ Vermeeren A: Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs. 2004;18(5):297-328. PMID 15089115
^ Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451
^ Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. PMID 18375
^ Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine] Arch Fr Pediatr. 1977 Jan;34(1):74-89. PMID 851373
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

Spoljašnje veze

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u vezi sa temama iz oblasti medicine (zdravlja).

[1] BE Patent 629005

[2] „Benzodiazepine Equivalence ”. Архивирано из оригинала 17. 07. 2007. г. Приступљено 07. 12. 2013.

[3] Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. PMID 2883820

[4] Vermeeren A: Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs. 2004;18(5):297-328. PMID 15089115

[5] Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451

[6] Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. PMID 18375

[7] Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine] Arch Fr Pediatr. 1977 Jan;34(1):74-89. PMID 851373

[8] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[9] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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