Dipeptidilna peptidaza IV
Dipeptidilna peptidaza IV (EC 3.4.14.5, dipeptidilna aminopeptidaza IV, Xaa-Pro-dipeptidil-aminopeptidaza, Gly-Pro naftilamidaza, postprolin dipeptidil aminopeptidaza IV, limfocitni antigen CD26, glikoprotein GP110, glicilprolinska aminopeptidaza, X-prolil dipeptidil aminopeptidaza, pep X, leukocitni antigen CD26, glicilprolil dipeptidilaminopeptidaza, dipeptidil-peptidna hidrolaza, glicilprolilna aminopeptidaza, dipeptidil-aminopeptidaza IV, DPP IV/CD26, amino acil-prolil dipeptidil aminopeptidaza, T ćelijski inicirajući molekul Tp103, X-PDAP) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dipeptidilna peptidaza IV | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.14.5 | ||||||||
| CAS broj | 54249-88-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Odvajanje N-terminalnog dipeptida, Xaa-Yaa--Zaa-, sa polipeptida, preferentno kad je Yaa: Pro, i kad Zaa nije Pro niti hidroksiprolin
Ovaj enzim je homodimer. On je integralni protein ćelijske membrane limfocita i drugih sisarskih ćelija.
Reference
уреди- ^ Misumi, Y., Hayashi, Y., Arakawa, F. and Ikehara, Y. (1992). „Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface”. Biochim. Biophys. Acta. 1131: 333—336. PMID 1352704.
- ^ David, F., Bernard, A.-M., Pierres, M. and Marguet, D. (1993). „Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases”. J. Biol. Chem. 268: 17247—17252. PMID 8102366.
- ^ Ikehara, Y., Ogata, S. and Misumi, Y. (1994). „Dipeptidyl-peptidase IV from rat liver”. Methods Enzymol. 244: 215—227. PMID 7845210.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Dipeptidyl-peptidase+IV на US National Library of Medicine Medical Subject Headings (MeSH)
