Diacilglicerol lipaza
Diacolglocerol lipaza (DAG lipaza, DAGL, DGL) je ključni enzim u biosintezi endokanabinoida 2-arahidonoilglicerol.[1] On katalizuje hidrolizu diacilglicerola, otpuštanjem slobodne masne kiseline i monoacilglicerola.
| Diacilglicerol lipaza, alfa | |
|---|---|
| Identifikatori | |
| Simbol | DAGLA |
| Alt. simboli | C11orf11 |
| Entrez | 747 |
| HUGO | 1165 |
| RefSeq | NM_006133 |
| UniProt | Q9Y4D2 |
| Ostali podaci | |
| EC broj | 3.1.1.- |
| Lokus | Hromozom 11 q12.3 |
| Diacilglicerol lipaza, beta | |
|---|---|
| Identifikatori | |
| Simbol | DAGLB |
| Entrez | 221955 |
| HUGO | 28923 |
| RefSeq | NM_139179 |
| UniProt | Q8NCG7 |
| Ostali podaci | |
| EC broj | 3.1.1.- |
| Lokus | Hromozom 7 p22.1 |
Dva zasebna gena koji kodiraju DGL enzime su klonirana, DGLα (DAGLA) i DGLβ (DAGLB). Oni imaju 33% identične sekvence.
Inhibitori
уредиOvaj enzim selektivno inhibiraju RHC80267 i tetrahidrolipstatin.
Reference
уреди- ^ Bisogno T; Howell F; Williams G; et al. (2003). „Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain”. J. Cell Biol. 163 (3): 463—8. PMC 2173631
. PMID 14610053. doi:10.1083/jcb.200305129.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Diacylglycerol+Lipase на US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.1.34
