CXCL5
CXCL5, hemokin (C-X-C motiv) ligand 5 protein je kod ljudi kodiran CXCL5 genom.[1][2] CXCL5 protein je mali citokin iz CXC hemokin familije koji je takođe poznat kao epitelijalni neutrofil-aktivirajući peptid 78 (ENA-78). On se proizvodi nakon stimulacije ćelija sa inflamatornim citokinima interleukin-1 ili tumor nekrozis faktorom-alfa.[3] CXCL5 ekspresija je takođe bila primećena u eosinofilima, i ona može biti inhibirana sa tip II interferonom IFN-γ.[4] Ovaj hemokin stimuliše hemotaksu neutrofila koji poseduje angiogene osobine. On pobuđuje te efekte putem interakcije sa hemokin receptorom CXCR2 na ćelijskoj površini.[4] CXCL5 gen je kodiran na četiri eksona. On je lociran na ljudskom hromozomu 4 zajedno sa nekoliko drugih CXC hemokin gena.[3][5] CXCL5 je bio impliciran u remodelovanje veznog tkiva.[4][6]
| Hemokin (C-X-C motiv) ligand 5 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | CXCL5; ENA-78; SCYB5 | ||||||||||
| Vanjski ID | OMIM: 600324 HomoloGene: 88672 GeneCards: CXCL5 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6374 | n/a | |||||||||
| Ensembl | ENSG00000163735 | n/a | |||||||||
| UniProt | P42830 | n/a | |||||||||
| RefSeq (mRNA) | NM_002994 | n/a | |||||||||
| RefSeq (protein) | NP_002985 | n/a | |||||||||
| Lokacija (UCSC) |
Chr 4: 75.08 - 75.08 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
Reference
уреди- ^ Chang MS, McNinch J, Basu R, Simonet S (1994). „Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene”. J Biol Chem. 269 (41): 25277—82. PMID 7929219.
- ^ „Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5”.
- ^ а б Chang MS, McNinch J, Basu R, Simonet S (1994). „Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene”. J. Biol. Chem. 269 (41): 25277—82. PMID 7929219. Архивирано из оригинала 13. 03. 2007. г. Приступљено 16. 07. 2010.
- ^ а б в Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). „Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils”. Clin. Exp. Allergy. 33 (4): 531—7. PMID 12680872. doi:10.1046/j.1365-2222.2003.01609.x.
- ^ O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209.
- ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
Literatura
уредиDodatna literatura
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- Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). „Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease.”. J. Leukoc. Biol. 62 (5): 604—11. PMID 9365115.
- Struyf S, Proost P, Van Damme J (2004). „Regulation of the immune response by the interaction of chemokines and proteases.”. Adv. Immunol. 81: 1—44. PMID 14711052. doi:10.1016/S0065-2776(03)81001-5.
- Walz A; Burgener R; Car B; et al. (1992). „Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8.”. J. Exp. Med. 174 (6): 1355—62. PMC 2119025
. PMID 1744577. doi:10.1084/jem.174.6.1355. - Power CA, Furness RB, Brawand C, Wells TN (1995). „Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets.”. Gene. 151 (1-2): 333—4. PMID 7828901. doi:10.1016/0378-1119(94)90682-3.
- Corbett MS, Schmitt I, Riess O, Walz A (1995). „Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78).”. Biochem. Biophys. Res. Commun. 205 (1): 612—7. PMID 7999089. doi:10.1006/bbrc.1994.2709.
- Koch AE; Kunkel SL; Harlow LA; et al. (1994). „Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis.”. J. Clin. Invest. 94 (3): 1012—8. PMC 295150 . PMID 8083342. doi:10.1172/JCI117414.
- Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). „Chemokine and chemokine receptor mRNA expression in human platelets.”. Cytokine. 7 (6): 479—82. PMID 8580362. doi:10.1006/cyto.1995.0065.
- Ahuja SK, Murphy PM (1996). „The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor.”. J. Biol. Chem. 271 (34): 20545—50. PMID 8702798. doi:10.1074/jbc.271.34.20545.
- Keates S; Keates AC; Mizoguchi E; et al. (1997). „Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis.”. Am. J. Physiol. 273 (1 Pt 1): G75—82. PMID 9252512.
- Wuyts A; Proost P; Lenaerts JP; et al. (1998). „Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78.”. Eur. J. Biochem. 255 (1): 67—73. PMID 9692902. doi:10.1046/j.1432-1327.1998.2550067.x.
- Wyrick PB; Knight ST; Paul TR; et al. (1999). „Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis.”. J. Infect. Dis. 179 (4): 954—66. PMID 10068592. doi:10.1086/314676.
- Wuyts A; Govaerts C; Struyf S; et al. (1999). „Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.”. Eur. J. Biochem. 260 (2): 421—9. PMID 10095777. doi:10.1046/j.1432-1327.1999.00166.x.
- Hogaboam CM; Bone-Larson CL; Steinhauser ML; et al. (1999). „Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines.”. FASEB J. 13 (12): 1565—74. PMID 10463948.
- Luu NT, Rainger GE, Nash GB (2000). „Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils.”. J. Immunol. 164 (11): 5961—9. PMID 10820279.
- Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). „Control of chemokine production at the blood-retina barrier.”. Immunology. 101 (3): 426—33. PMC 2327097 . PMID 11106948. doi:10.1046/j.0019-2805.2000.01105.x.
- Zhang C; Thornton MA; Kowalska MA; et al. (2001). „Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.”. Blood. 98 (3): 610—7. PMID 11468158. doi:10.1182/blood.V98.3.610.
- Chandrasekar B; Melby PC; Sarau HM; et al. (2003). „Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway.”. J. Biol. Chem. 278 (7): 4675—86. PMID 12468547. doi:10.1074/jbc.M207006200.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Spoljašnje veze
уреди- Platelet+factor+5 на US National Library of Medicine Medical Subject Headings (MeSH)