CD153

Faktor nekroze tumora (ligand) superfamilija, član 8
Faktor nekroze tumora (ligand) superfamilija, član 8
Identifikatori
Simbol	TNFSF8
Alt. simboli	CD30LG
Entrez	944
HUGO	11938
OMIM	603875
RefSeq	NM_001244
UniProt	P32971
Ostali podaci
Lokus	Hromozom 9 q33

CD153, ili Klaster diferencijacije 153, je ligand za CD30.^[1]

CD30, je član TNFR familije, i izražen je aktiviranim CD4+ i CD8+ T ćelijama i B ćelijama. On je maker [[Hodžkinsov limfom|Hodžkinsovog limfoma]]. Ligand ovog receptora, CD30L (CD153), je izražen u aktiviranim CD4+ i CD8+ T ćelijama, B ćelijama, i makrofagama. Signaliziranje kroz CD30 možed da dovede do proliferacije ili ćelijske smrti. CD30-deficitarni (-/-) miševi imaju sputanu timičnu negativnu selekciju i povećanu autoreaktivnost.^[2]

Vidi još

Klasteri diferencijacije

Literatura

^ Cerutti A, Schaffer A, Goodwin RG, Shah S, Zan H, Ely S, Casali P (2000). „Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells”. J Immunol. 165 (2): 786—94. PMID 10878352.
^ Bruce R. Blazar; Robert B. Levy; Tak W. Mak; Angela Panoskaltsis-Mortari; Hiromi Muta; Monica Jones; Melinda Roskos; Jonathan S. Serody; Hideo Yagita; Eckhard R. Podack & Patricia A. Taylor (2004). „CD30/CD30 Ligand (CD153) Interaction Regulates CD4 + T Cell-Mediated Graft-versus-host disease”. Journal of immunology. The American Association of Immunologists, Inc. 173 (5): 2933—2941.

Spoljašnje veze

CD153+Antigen на US National Library of Medicine Medical Subject Headings (MeSH)

[Cerutti-1] Cerutti A, Schaffer A, Goodwin RG, Shah S, Zan H, Ely S, Casali P (2000). „Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells”. J Immunol. 165 (2): 786—94. PMID 10878352.

[Blazar-2] Bruce R. Blazar; Robert B. Levy; Tak W. Mak; Angela Panoskaltsis-Mortari; Hiromi Muta; Monica Jones; Melinda Roskos; Jonathan S. Serody; Hideo Yagita; Eckhard R. Podack & Patricia A. Taylor (2004). „CD30/CD30 Ligand (CD153) Interaction Regulates CD4 + T Cell-Mediated Graft-versus-host disease”. Journal of immunology. The American Association of Immunologists, Inc. 173 (5): 2933—2941.

[1]

[2]