CCL24

Hemokin (C-C motiv) ligand 24
Hemokin (C-C motiv) ligand 24
Identifikatori
Simbol	CCL24
Alt. simboli	SCYA24, Ckb-6, MPIF-2, eotaxin-2
Entrez	6369
HUGO	10623
OMIM	602495
PDB	1EIG
RefSeq	NM_002991
UniProt	O00175
Ostali podaci
Lokus	Hromozom 7 q11.23

CCL24, hemokine (C-C motiv) ligand 24, takođe poznat kao mijeloidni progenitor inhibitorni faktor 2 (MPIF-2), ili eozinofilni hemotaksni protein 2 (eotaksin-2), je protein koji je kod ljudi kodiran CCL24 genom.^[1] Taj gen je lociran na ljudskom hromozomu 7.^[2]^[3]

Funkcija

CCL24 je mali citokin iz CC hemokin familije. CCL24 interaguje sa hemokinskim receptorom CCR3 i indukuje hemotaksu eozinofila.^[4] Ovaj hemokin je takođe snažno hemotaksan za neaktivirane T limfocite, i u manjoj meri privlači neutrofile.^[1]

Klinički značaj

Povišeni nivoi eotaksina-2 su promećeni kod pacijenata sa aspirin pogoršanim respiratornim bolestima, kao što je astma. Ljudi kod kojh su nivoi eotaksina-2 u plazmi niži nisu pokazivali tendenciju ka razvijanju aspirin uzrokovane astme.^[5]

Reference

^ ^а ^б Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (1997). „Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors”. J. Exp. Med. 185 (7): 1163—72. PMC 2196270  . PMID 9104803.
^ Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (1997). „Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils”. J. Leukoc. Biol. 62 (5): 667—75. PMID 9365122.
^ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (2009). „Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease”. Allergy. PMID 19796209. doi:10.1111/j.1398-9995.2009.02158.x.

Literatura

Spoljašnje veze

CCL24 GeneCard

[pmid9104803-1] а ^б Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (1997). „Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors”. J. Exp. Med. 185 (7): 1163—72. PMC 2196270  . PMID 9104803.

[pmid12853948-2] Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[pmid9365122-4] White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (1997). „Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils”. J. Leukoc. Biol. 62 (5): 667—75. PMID 9365122.

[pmid19796209-5] Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (2009). „Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease”. Allergy. PMID 19796209. doi:10.1111/j.1398-9995.2009.02158.x.

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