CCL15
CCL15, hemokin (C-C motif) ligand 15, je mali citokin iz CC hemokin familiji koji je poznat kao leukotaktin-1, MIP5 i HCC-2. CCL15 je izražen u jetri, tankim crevima, kolonu, i u pojedinim tipovima leukocita i makrofaga u plućima.[1] CCL15 je hemotaksan za neutrofile, monocite, i limfocite. On dejstvuje putem vezivanja za hemokinske receptore na ćelijskoj površini poput CCR1 i CCR3.[2][3] Ljudski CCL15 gen sadrži četiri eksona i lociran je na hromozomu 17 zajedno sa ja još jednim CC hemokinom poznatim kao CCL14.[4][5]
| Hemokin (C-C motiv) ligand 15 | |
|---|---|
| Identifikatori | |
| Simbol | CCL15 |
| Alt. simboli | SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B |
| Entrez | 6359 |
| HUGO | 10613 |
| OMIM | 601393 |
| PDB | 2HCC |
| RefSeq | NM_032965 |
| UniProt | Q16663 |
| Ostali podaci | |
| Lokus | Hromozom 17 q11.2 |
Reference
уреди- ^ Pardigol; et al. (1998). „HCC-2, a human chemokine: gene structure, expression pattern, and biological activity”. Proc. Nat. Acad. Sci. 95: 6308—6313.
- ^ Youn; et al. (1997). „Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3.”. J. Immun. 159: 5201—5205.
- ^ Coulin; et al. (1997). „Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines”. Europ. J. Biochem. 248: 507—515.
- ^ Naruse; et al. (1996). „A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2”. Genomics. 34: 236—240.
- ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.