Aspartat transaminaza
Aspartat transaminaza (EC 2.6.1.1, glutaminska-oksaloacetatna transaminaza, glutaminska-aspartinska transaminaza, transaminaza A, AAT, AspT, 2-oksoglutarat-glutamatna aminotransferaza, aspartat alfa-ketoglutaratna transaminaza, aspartatna aminotransferaza, aspartat-2-oksoglutaratna transaminaza, aspartinsko kiselinska aminotransferaza, aspartinska aminotransferaza, aspartilna aminotransferaza, AST, glutamat-oksalacetatna aminotransferaza, glutamat-oksalatna transaminaza, glutaminska-aspartinska aminotransferaza, glutaminska-oksalacetatna transaminaza, glutaminska oksalinska transaminaza, GOT (enzim), L-aspartatna transaminaza, L-aspartat-alfa-ketoglutaratna transaminaza, L-aspartat-2-ketoglutaratna aminotransferaza, L-aspartat-2-oksoglutaratna aminotransferaza, L-aspartat-2-oksoglutaratna transaminaza, L-aspartinska aminotransferaza, oksaloacetat-aspartatna aminotransferaza, oksaloacetatna transferaza, aspartat:2-oksoglutaratna aminotransferaza, glutamat oksaloacetatna transaminaza) je enzim sa sistematskim imenom L-aspartat:2-oksoglutarat aminotransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aspartat transaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.6.1.1 | ||||||||
| CAS broj | 9000-97-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-aspartat + 2-oksoglutarat oksaloacetat + L-glutamat
Ovaj enzim je piridoksal-fosfatni protein.
Reference
уреди- ^ Banks, B.E.C. & Vernon, C.A. (1961). „Transamination. Part I. The isolation of the apoenzyme of glutamic-aspartic transaminase from pig heart muscle”. J. Chem. Soc. (Lond.): 1698—1705.
- ^ Bertland, L.H. & Kaplan, N.O. (1968). „Chicken heart soluble aspartate aminotransferase. Purification and properties”. Biochemistry. 7: 134—142. PMID 5758538.
- ^ Forest, J.C. & Wightman, F. (1973). „Amino acid metabolism in plants. III. Purification and some properties of a multispecific aminotransferase isolated from bushbean seedlings (Phaseolus vulgaris L.)”. Can. J. Biochem. 50: 813—829.
- ^ Henson, C.P. & Cleland, W.W. (1964). „Kinetic studies of glutamic oxaloacetic transaminase isozymes”. Biochemistry. 3: 338—345. PMID 14155095.
- ^ Jenkins, W.T.; Yphantis, D.A.; Sizer, I.W. (1959). „Glutamic aspartic transaminase. I. Assay, purification, and general properties”. J. Biol. Chem. 234: 51—57. PMID 13610891.
- ^ Lowe, P.N. & Rowe, A.F. (1985). „Aspartate: 2-oxoglutarate aminotransferase from Trichomonas vaginalis. Identity of aspartate aminotransferase and aromatic amino acid aminotransferase”. Biochem. J. 232: 689—695. PMID 3879173.
- ^ Mavrides, C. & Orr, W. (1975). „Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli”. J. Biol. Chem. 250: 4128—4133. PMID 236311.
- ^ Schreiber, G.; Eckstein, M.; Oeser, A.; Holzer, H. (1964). „[The concentration of aspartate aminotransferase from brewers’ yeast]”. Biochem. Z. 340: 13—20. PMID 14317947.
- ^ Shrawder, E. & Martinez-Carrion, M. (1972). „Evidence of phenylalanine transaminase activity in the isoenzymes of aspartate transaminase”. J. Biol. Chem. 247: 2486—2492. PMID 4623131.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Aspartate+transaminase на US National Library of Medicine Medical Subject Headings (MeSH)
