2-Aminotetralin

2-Aminotetralin
IUPAC ime
	1,2,3,4-tetrahidronaftalen-2-amin
Klinički podaci
Način primene	Oralno
Pravni status
Pravni status	Nije kontrolisana supstanca;
Identifikatori
CAS broj	2954-50-9
ATC kod	none
PubChem	CID 34677
ChemSpider	31912
ChEMBL	CHEMBL30294
Hemijski podaci
Formula	C10H13N
Molarna masa	147,217 g/mol
	SMILES C1CC2=CC=CC=C2CC1N; ;
	InChI InChI=1S/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4,10H,5-7,11H2 ; Key:LCGFVWKNXLRFIF-UHFFFAOYSA-N ;

'2-Aminotetralin (2-AT, 1,2,3,4-tetrahidronaftalen-2-amin, THN) je stimulansni lek. Njegova hemijska struktura se sastoji od tetralinske grupe sa aminskim supstituentom.^[1]^[2]

2-AT je krut analog fenilizobutilamina. On potpuno zamenjuje d-amfetamin u testovima diskriminacije na pacovima, mada ima jednu osminu potentnosti.^[1] Pokazano je da inhibira ponovno preuzimanje serotonina i norepinefrina, te da verovatno indukuje njihovo otpuštanje.^[3]^[4] Verovatno je da ima uticaja na dopamin jer potpuno zamenjuje d-amfetamin u studijama na glodarima.^[1]

Hemijski derivati

Postoji znatan broj derivata 2-aminotetralina, među kojima su:

Reference

^ ^а ^б ^в Oberlender R, Nichols DE. (1991). „Structural variation and (+)-amphetamine-like discriminative stimulus properties.”. Pharmacol Biochem Behav. 38 (3): 581—586. PMID 2068194. doi:10.1016/0091-3057(91)90017-V.
^ Marley E, Stephenson JD (1971). „Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections”. British Journal of Pharmacology. 42 (4): 522—42. PMC 1665761  . PMID 5116035.
^ Bruinvels J (1971). „Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain”. British Journal of Pharmacology. 42 (2): 281—6. PMC 1667157  . PMID 5091160.
^ Bruinvels J, Kemper GC (1971). „Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat”. British Journal of Pharmacology. 43 (1): 1—9. PMC 1665934  . PMID 4257629.

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[pmid2068194-1] а ^б ^в Oberlender R, Nichols DE. (1991). „Structural variation and (+)-amphetamine-like discriminative stimulus properties.”. Pharmacol Biochem Behav. 38 (3): 581—586. PMID 2068194. doi:10.1016/0091-3057(91)90017-V.

[pmid5116035-2] Marley E, Stephenson JD (1971). „Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections”. British Journal of Pharmacology. 42 (4): 522—42. PMC 1665761  . PMID 5116035.

[pmid5091160-3] Bruinvels J (1971). „Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain”. British Journal of Pharmacology. 42 (2): 281—6. PMC 1667157  . PMID 5091160.

[pmid4257629-4] Bruinvels J, Kemper GC (1971). „Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat”. British Journal of Pharmacology. 43 (1): 1—9. PMC 1665934  . PMID 4257629.

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