Amin N-metiltransferaza
Amin N-metiltransferaza (EC 2.1.1.49, nikotinska N-metiltransferaza, triptaminska N-metiltransferaza, arilaminska N-metiltransferaza, triptaminska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:amin N-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Amin N-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.49 | ||||||||
| CAS broj | 111694-10-1&title= 51377-47-0, 111694-10-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + an amin S-adenozil-L-homocistein + metilisani amin
Ovaj enzim ima veoma široku specifičnost. Mnogi primarni, sekundarni i tercijarni amini mogu da deluju kao akceptori, uključujući triptamin, anilin, nikotin i mnoštvo lekova i drugih ksenobiotika.
Reference
уреди- ^ Ansher, S.S. & Jakoby, W.B. (1986). „Amine N-methyltransferases from rabbit liver”. J. Biol. Chem. 261: 3996—4001. PMID 3949799.
- ^ Crooks, P.A., Godin, C.S., Damani, L.A., Ansher, S.S. and Jakoby, W.B. (1988). „Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases”. Biochem. Pharmacol. 37: 1673—1677. PMID 3377829.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Amine+N-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
