7-Spiroindaniloksimorfon

7-Spiroindaniloksimorfon
IUPAC ime
	(4aR-(4aα,7aα,8α,9cα))- 1',3',7,7a,8,9- Hexahydro- 3,7a-dihydroxy- 12-methylspiro (6H-8,9c- (iminoethano) phenanthro (4,5-bcd) furan- 6,2'- (2H)inden)- 5(4aH)- one
Identifikatori
CAS broj	150380-34-0
PubChem	CID 5487084
ChemSpider	8176808
Hemijski podaci
Formula	C25H25NO4
Molarna masa	403.470 g/mol
	SMILES CN1CCC23[C@@H]4C(=O)C5(CC6=CC=CC=C6C5)C[C@]2([C@@H]1CC7=C3C(=C(C=C7)O)O4)O; ;
	InChI InChI=1S/C25H25NO4/c1-26-9-8-24-19-14-6-7-17(27)20(19)30-22(24)21(28)23(13-25(24,29)18(26)10-14)11-15-4-2-3-5-16(15)12-23/h2-7,18,22,27,29H,8-13H2,1H3/t18?,22-,24-,25+/m0/s1 ; Key:YJWDKWRVFJZBCJ-OVKCVFHGSA-N ;

7-Spiroindaniloksimorfon (SIOM) je lek koji se koristi u naučnim istraživanjima. On je selektivni δ-opioidni agonist.^[1]^[2]^[3]^[4]^[5]

Reference

^ Portoghese PS, Moe ST, Takemori AE (1993). „A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists”. Journal of medicinal chemistry. 36 (17): 2572—4. PMID 8394935.
^ Fang X, Larson DL, Portoghese PS (1997). „7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands”. Journal of medicinal chemistry. 40 (19): 3064—70. PMID 9301669. doi:10.1021/jm970283e.
^ Ohkawa S, Digiacomo B, Larson DL, Takemori AE, Portoghese PS (1997). „7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors”. Journal of medicinal chemistry. 40 (11): 1720—5. PMID 9171881. doi:10.1021/jm9700880.
^ Kshirsagar TA, Fang X, Portoghese PS (1998). „14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors”. Journal of medicinal chemistry. 41 (14): 2657—60. PMID 9651172. doi:10.1021/jm980209b.
^ Shenderovich MD, Liao S, Qian X, Hruby VJ (2000). „A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands”. Biopolymers. 53 (7): 565—80. PMID 10766952. doi:10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5.

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